2-APB
Product Information
Molecular Formula
C14H16BNO
Molecular Weight
225.10
Description
2-APB, a transient receptor potential (TRP) activator for TRPV1, TRPV2, and TRPV3, could probably be used against diseases caused by hypersensitivity and temperature misregulation.
Synonyms
2-Aminoethoxydiphenylborane
IUPAC Name
2-diphenylboranyloxyethanamine
SMILES
B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN
InChI
InChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChI Key
BLZVCIGGICSWIG-UHFFFAOYSA-N
Flash Point
Not applicable
Purity
≥98% by HPLC
Appearance
White Solid
Storage
−20°C
Safety Information
Hazards
H315 - H319 - H335
Precautionary Statement
P302 + P352 - P305 + P351 + P338
Computed Properties
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
5
Exact Mass
225.1324943 g/mol
Monoisotopic Mass
225.1324943 g/mol
Topological Polar Surface Area
35.2Ų
Heavy Atom Count
17
Formal Charge
0
Complexity
182
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113546086-A | Application of 2-APB in preparation of medicine for promoting skin wound healing | 2021-09-10 |
| CN-112426425-A | Use of citrusinine-II for the preparation of agents affecting the perception of itch and pain in humans and animals | 2020-11-20 |
| CN-112426425-B | Use of citrusinine-II for the preparation of agents affecting the perception of itch and pain in humans and animals | 2020-11-20 |
| WO-2021248160-A1 | Methods of treatment of a cytokine storm | 2020-06-01 |
| FR-3110393-A1 | COMPOUND AND COMPOSITION TO INDUCE NEUROPROTECTION | 2020-05-20 |
| WO-2021234324-A1 | Compound and composition for inducing neuroprotection | 2020-05-20 |
| US-2021363163-A1 | Organic electroluminescent materials and devices | 2020-05-13 |
| EP-3910030-A1 | Bioinspired fluorescent stains for reversible labelling of the endoplasmic reticulum and for further analytical applications | 2020-05-11 |
| WO-2021228776-A1 | Bioinspired fluorescent probes for reversible staining of the endoplasmic reticulum and for further analytical applications | 2020-05-11 |
| JP-2021172628-A | Selective TRP channel activators and their uses | 2020-04-28 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 34516972 | 2021-10-01 | Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis | Chemico-biological interactions |
| 33408296 | 2021-01-01 | Bisphenol A stabilizes Nrf2 via Ca2+ influx by direct activation of the IP3 receptor | The Journal of toxicological sciences |
| 32578922 | 2020-11-01 | Perfluorooctanoic acid activates the unfolded protein response in pancreatic acinar cells | Journal of biochemical and molecular toxicology |
| 32522522 | 2020-08-01 | Ca2+/CaM/CaMK signaling is involved in cadmium-induced osteoclast differentiation | Toxicology |
| 31982503 | 2020-05-01 | ZEA-induced autophagy in TM4 cells was mediated by the release of Ca2+ activates CaMKKβ-AMPK signaling pathway in the endoplasmic reticulum | Toxicology letters |
| 30229906 | 2019-04-01 | A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species-induced delayed cell death | Journal of cellular physiology |
| 30615643 | 2019-01-01 | TRPM7 residue S1269 mediates cAMP dependence of Ca2+ influx | PloS one |
| 30076216 | 2018-09-14 | TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis | The Journal of biological chemistry |
| 29883672 | 2018-08-01 | CaMKⅡ mediates cadmium induced apoptosis in rat primary osteoblasts through MAPK activation and endoplasmic reticulum stress | Toxicology |
| 28347754 | 2017-05-15 | Cadmium disrupts autophagic flux by inhibiting cytosolic Ca2+-dependent autophagosome-lysosome fusion in primary rat proximal tubular cells | Toxicology |
