2-(Di-tert-butylphosphino)dimethylaminobenzene
Product Information
Molecular Formula
C16H28NP
Molecular Weight
265.37
Description
2-(Di-tert-butylphosphino)dimethylaminobenzene is a biomedical compound used as a ligand in catalytic transformations. It's especially prominent in the development of antitumor drugs targeting platinum-based chemotherapeutics for cancers due to its high reactivity with platinum ions.
Synonyms
2-(Di-tert-butylphosphino)-N,N-dimethylaniline,Di-tert-butyl(2-dimethylaminophenyl)phosphine
IUPAC Name
2-ditert-butylphosphanyl-N,N-dimethylaniline
SMILES
CC(C)(C)P(C1=CC=CC=C1N(C)C)C(C)(C)C
InChI
InChI=1S/C16H28NP/c1-15(2,3)18(16(4,5)6)14-12-10-9-11-13(14)17(7)8/h9-12H,1-8H3
InChI Key
NTJPAGHACOIILD-UHFFFAOYSA-N
Melting Point
50-53 °C
Flash Point
Not applicable
Purity
97%
Computed Properties
XLogP3
3.6
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
4
Exact Mass
265.195936895 g/mol
Monoisotopic Mass
265.195936895 g/mol
Topological Polar Surface Area
3.2Ų
Heavy Atom Count
18
Formal Charge
0
Complexity
245
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| KR-20210151833-A | Macrocyclic azolopyridine derivatives as EED and PRC2 modulators | 2019-03-15 |
| WO-2020152200-A1 | Process for preparation of heteroarylketones | 2019-01-25 |
| US-2019033185-A1 | High Throughput Methods for Screening Chemical Reactions Using Reagent-Coated Bulking Agents | 2017-07-31 |
| US-2019383712-A9 | High Throughput Methods for Screening Chemical Reactions Using Reagent-Coated Bulking Agents | 2017-07-31 |
| US-9701692-B1 | Synthesis of thienothiophenes | 2016-03-11 |
| JP-2019501222-A | Selective inhibitors of clinically important variants of EGFR tyrosine kinase | 2016-01-07 |
| MX-2014010377-A | HETEROBICICLIC COMPOUNDS. | 2012-02-29 |
| KR-20140103328-A | Disubstituted benzothienyl-pyrrolotriazines and uses thereof as FGFR kinase inhibitors | 2011-12-15 |
| KR-20140098050-A | Benzofluorene compound, material for luminescent layer using said compound and organic electroluminescent device | 2011-11-25 |
| JP-2012214707-A | Process for producing aromatic polymer | 2011-03-29 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 20024992 | 2010-02-08 | A highly versatile catalyst system for the cross-coupling of aryl chlorides and amines | Chemistry (Weinheim an der Bergstrasse, Germany) |
