3-Hydroxyphthalic Anhydride
Product Information
Molecular Formula
C8H4O4
Molecular Weight
164.11
Description
3-Hydroxyphthalic Anhydride (CAS# 37418-88-5) is used to synthesize 3-Hydroxyphthalic Anhydride-modified human serum albumin whichhas high potency as a microbicide for prevention of the sexual transmission of HIV. It is also used as a reagent in organicsynthesis of other compounds including that of inhibitors of NF-κB derived from thalidomide.
Synonyms
4-hydroxyisobenzofuran-1,3-dione; 4-hydroxy-2-benzofuran-1,3-dione
IUPAC Name
4-hydroxy-2-benzofuran-1,3-dione
SMILES
C1=CC2=C(C(=C1)O)C(=O)OC2=O
InChI
InChI=1S/C8H4O4/c9-5-3-1-2-4-6(5)8(11)12-7(4)10/h1-3,9H
InChI Key
CCTOEAMRIIXGDJ-UHFFFAOYSA-N
Boiling Point
365.4 °C at 760 mmHg
Melting Point
199-202 °C (lit.)
Purity
98 %
Density
1.625 g/cm3
LogP
0.70280
Safety Information
Hazards
H315 - H319 - H335
Precautionary Statement
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word
Warning
Computed Properties
XLogP3
1.5
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
0
Exact Mass
164.01095860 g/mol
Monoisotopic Mass
164.01095860 g/mol
Topological Polar Surface Area
63.6Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
235
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113925168-A | Application of EGCG quinone as inhibitor for resisting AGEs (angiotensin-converting enzyme) release in gastrointestinal tract | 2021-10-28 |
| CN-113979996-A | Phthalimide fluorescent probe for detecting copper ions, preparation method and application thereof, and copper ion detection method | 2021-10-27 |
| CN-113686828-A | CdTe quantum dot-based ratiometric fluorescent probe and application thereof in hydrazine hydrate detection | 2021-08-25 |
| CN-113171445-A | Modified beta-lactoglobulin and biological preparation for preventing and treating HPV (human papillomavirus) virus infection | 2021-04-30 |
| CN-112891520-A | Preparation method of active biological protein for preventing and controlling Human Papilloma Virus (HPV) infection | 2021-04-13 |
| CN-112980194-A | LED packaging material and preparation method thereof | 2021-03-04 |
| CN-112999358-A | Bioactive protein for preventing and treating human papilloma virus infection, preparation method and application thereof | 2021-03-04 |
| TW-I739715-B | Polyimide resin composition, polyimide resin adhesive layer, laminate, and manufacturing method of electronic component | 2021-02-26 |
| CN-112500570-A | Flexible display device, polyamic acid varnish for display, and polyimide film | 2021-02-04 |
| CN-112500570-B | Flexible display device, polyamic acid varnish for display, and polyimide film | 2021-02-04 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22819190 | 2012-08-15 | Design and synthesis of marine fungal phthalide derivatives as PPAR-γ agonists | Bioorganic & medicinal chemistry |
| 21764688 | 2011-06-01 | [Antiviral activity of 3-hydroxyphthalic anhydride-modified ovalbumin against herpes simplex virus 2 in vitro] | Nan fang yi ke da xue xue bao = Journal of Southern Medical University |
| 21239999 | 2011-04-15 | Combinations of 3-hydroxyphthalic anhydride-modified ovalbumin with antiretroviral drug-based microbicide candidates display synergistic and complementary effects against HIV-1 infection | Journal of acquired immune deficiency syndromes (1999) |
| 20420669 | 2010-04-26 | Maleic anhydride-modified chicken ovalbumin as an effective and inexpensive anti-HIV microbicide candidate for prevention of HIV sexual transmission | Retrovirology |
| 12834857 | 2003-06-01 | The antiviral activity of naturally occurring proteins and their peptide fragments after chemical modification | Antiviral research |
| 11388489 | 2001-04-01 | 7-Hydroxyphthalide: a new natural salicylaldehyde analog from Oulenzia sp. (Astigmata: Winterschmitiidae) | Bioscience, biotechnology, and biochemistry |
| 11272824 | 2001-01-01 | Synthesis of corollosporine, an antibacterial metabolite of the marine fungus Corollospora maritima | Bioscience, biotechnology, and biochemistry |
