4,4'-Cyclohexylidenebisphenol
Product Information
Molecular Formula
C18H20O2
Molecular Weight
268.35
Description
Applications: Bisphenol Z is one of the many derivatives of Bisphenol A (B519495) that can be used as HIF (hypoxia-inducible factor) inhibitors, antitumor agents, angiogenesis inhibitors, and antihypoxic agents.
Synonyms
Bisphenol Z
IUPAC Name
4-[1-(4-hydroxyphenyl)cyclohexyl]phenol
SMILES
C1CCC(CC1)(C2=CC=C(C=C2)O)C3=CC=C(C=C3)O
InChI
InChI=1S/C18H20O2/c19-16-8-4-14(5-9-16)18(12-2-1-3-13-18)15-6-10-17(20)11-7-15/h4-11,19-20H,1-3,12-13H2
InChI Key
SDDLEVPIDBLVHC-UHFFFAOYSA-N
Boiling Point
440.9°C at 760 mmHg
Melting Point
190-192°C
Purity
95%
Density
1.166 g/cm3
Appearance
White powder
Storage
Room Temperature
Refractive Index
1.5490 (estimate)
Safety Information
Hazards
H361:
Suspected of damaging fertility or the unborn child.
H411:
Toxic to aquatic life with long-lasting effects.
Suspected of damaging fertility or the unborn child.
H411:
Toxic to aquatic life with long-lasting effects.
Precautionary Statement
P201:
Obtain special instructions before use.
P273:
Avoid release to the environment.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:
If exposed or concerned:
Get medical advice/attention.
P391:
Collect spillage.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Obtain special instructions before use.
P273:
Avoid release to the environment.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:
If exposed or concerned:
Get medical advice/attention.
P391:
Collect spillage.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Computed Properties
XLogP3
5.4
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
2
Exact Mass
268.146329876 g/mol
Monoisotopic Mass
268.146329876 g/mol
Topological Polar Surface Area
40.5Ų
Heavy Atom Count
20
Formal Charge
0
Complexity
269
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114100658-A | Carbon nitride/tungsten trioxide/sulfur-doped antimony oxychloride double-Z-shaped composite photocatalyst and preparation method and application thereof | 2021-11-23 |
| CN-114057992-A | Resin composition for carbon fiber molding | 2021-11-02 |
| CN-113817169-A | High-temperature-resistant block polysulfate and preparation method thereof | 2021-11-01 |
| CN-113956441-A | Die pressing free radical modified epoxy resin composition | 2021-10-29 |
| CN-113637153-A | Multi-block polyether type high-molecular surfactant and preparation method and application thereof | 2021-10-18 |
| CN-113637154-A | Nonionic polyether type high-molecular surfactant and preparation method and application thereof | 2021-10-18 |
| CN-113637155-A | Anionic polyether type high-molecular surfactant and preparation method thereof | 2021-10-18 |
| JP-2022009110-A | Delamination resin film, interlayer insulation resin film with adhesive auxiliary layer, and printed wiring board | 2021-10-13 |
| CN-113671794-A | Positive photoresist and preparation method thereof, preparation method of glass shell and electronic equipment | 2021-08-25 |
| CN-113820932-A | Negative electricity three-layer OPC drum | 2021-08-20 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 34499926 | 2021-11-01 | Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β | The Journal of biological chemistry |
| 34299453 | 2021-07-09 | Study on the Joint Toxicity of BPZ, BPS, BPC and BPF to Zebrafish | Molecules (Basel, Switzerland) |
| 32387340 | 2020-07-15 | Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor α | Toxicology and applied pharmacology |
| 31836225 | 2020-05-15 | A tiered high-throughput screening approach for evaluation of estrogen and androgen receptor modulation by environmentally relevant bisphenol A substitutes | The Science of the total environment |
| 31388671 | 2019-11-01 | Characterization of Estrogenic and Androgenic Activities for Bisphenol A-like Chemicals (BPs): In Vitro Estrogen and Androgen Receptors Transcriptional Activation, Gene Regulation, and Binding Profiles | Toxicological sciences : an official journal of the Society of Toxicology |
| 31195007 | 2019-08-15 | Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors | Toxicology and applied pharmacology |
| 31289329 | 2019-07-09 | Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors | Scientific reports |
| 30951782 | 2019-05-15 | Functional profiling of bisphenols for nuclear receptors | Toxicology |
| 30639807 | 2019-04-01 | Comparison of thyroid hormone disruption potentials by bisphenols A, S, F, and Z in embryo-larval zebrafish | Chemosphere |
| 30582956 | 2019-02-01 | Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors | Toxicology |
