4-Methoxypicolinimidamide hydrochloride

Product Information

Molecular Formula:
C7H10ClN3O
Molecular Weight:
187.63
Description
This pyridyl carboxamidine ligand has been demonstrated by Daniel Weix's lab to enable nickel-catalyzed cross-coupling of diverse basic nitrogen heterocycles with primary and secondary alkyl halides.
Synonyms
Weix 2-pyridylcarboxamidine ligand for nickel catalysis
IUPAC Name
4-methoxypyridine-2-carboximidamidehydrochloride
Canonical SMILES
COC1=CC(=NC=C1)C(=N)N.Cl
InChI
InChI=1S/C7H9N3O.ClH/c1-11-5-2-3-10-6(4-5)7(8)9/h2-4H,1H3,(H3,8,9)1H
InChI Key
JOUDWIBACXLPIO-UHFFFAOYSA-N
Melting Point
174-176 °C
Flash Point
Not applicable
Purity
≥95%

Computed Properties

Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
2
Exact Mass
187.0512396 g/mol
Monoisotopic Mass
187.0512396 g/mol
Topological Polar Surface Area
72Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
149
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
2
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
EP-3892615-A1 Process for the preparation of silodosin 2020-04-09
WO-2021205023-A1 Process for the preparation of silodosin 2020-04-09
US-2020339559-A1 Heterocyclic compounds and their use for treatment of helminthic infections and diseases 2019-04-26
WO-2020219871-A1 Heterocyclic compounds and their use for treatment of helminthic infections and diseases 2019-04-26
CN-114072395-A Heterocyclic compounds and their use for treating helminth infections and diseases 2019-04-26
EP-3959207-A1 Heterocyclic compounds and their use for treatment of helminthic infections and diseases 2019-04-26
WO-2020165834-A1 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
AU-2020222346-A1 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
CA-3123519-A1 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
AU-2020222346-B2 Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof 2019-02-15
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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