6-Fluoropyridine-3-boronic Acid
Product Information
Molecular Formula
C5H5FNO2B
Molecular Weight
140.91
Description
Used in a synthesis of halohydroxypyridines by hydroxydeboronation with basic hydrogen peroxide.
Synonyms
(6-fluoro-3-pyridinyl)boronic acid; (6-fluoropyridin-3-yl)boronic acid
IUPAC Name
(6-fluoropyridin-3-yl)boronic acid
SMILES
B(C1=CN=C(C=C1)F)(O)O
InChI
InChI=1S/C5H5BFNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3,9-10H
InChI Key
OJBYZWHAPXIJID-UHFFFAOYSA-N
Boiling Point
311.5 °C at 760 mmHg
Flash Point
Not applicable
Density
1.34 g/cm3
LogP
-1.09950
Safety Information
Hazards
H315 - H319 - H335
Precautionary Statement
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word
Warning
Computed Properties
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
1
Exact Mass
141.0397367 g/mol
Monoisotopic Mass
141.0397367 g/mol
Topological Polar Surface Area
53.4Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
114
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113321668-A | Synthesis of serpatatinib | 2021-06-21 |
| CN-112915205-A | Photosensitizer/enzyme combination delivery system for anti-tumor photodynamic sensitization therapy and preparation method thereof | 2021-02-03 |
| CN-112687878-A | Electrochemical device and electronic device | 2020-12-25 |
| WO-2022037643-A1 | Heteroaromatic ring compound as ret kinase inhibitor, and preparation and use thereof | 2020-08-20 |
| WO-2022038116-A1 | N-hydroxycarboxamide derivatives useful as inhibitors of mammalian histone deacetylase activity | 2020-08-19 |
| AU-2021203261-B1 | Novel dioxoloisoquinolinone derivatives and use thereof | 2020-08-13 |
| KR-20220021319-A | Novel dioxoloisoquinolinone derivatives and use thereof | 2020-08-13 |
| WO-2022035303-A1 | Novel dioxoloisoquinolinone derivatives and use thereof | 2020-08-13 |
| WO-2022026892-A1 | Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers | 2020-07-31 |
| WO-2022023339-A1 | Aryl substituted pyrrolo-pyridinones and therapeutic uses thereof | 2020-07-29 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 18983140 | 2008-11-27 | Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase | Journal of medicinal chemistry |
