6-Fluoropyridine-3-boronic Acid Pinacol Ester
Product Information
Molecular Formula
C11H15FNO2B
Molecular Weight
223.05
Description
6-Fluoropyridine-3-boronic Acid Pinacol Ester (CAS# 444120-95-0) is a useful research chemical.
Synonyms
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
IUPAC Name
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
SMILES
B1(OC(C(O1)(C)C)(C)C)C2=CN=C(C=C2)F
InChI
InChI=1S/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3
InChI Key
ZKSRQMCKFLGPQU-UHFFFAOYSA-N
Boiling Point
304.208 °C at 760 mmHg
Melting Point
29-33 °C (lit.)
Purity
≥ 95 %
Density
1.1 g/cm3
LogP
1.51990
Safety Information
Hazards
H315 - H319 - H335
Precautionary Statement
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word
Warning
Computed Properties
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
1
Exact Mass
223.1179870 g/mol
Monoisotopic Mass
223.1179870 g/mol
Topological Polar Surface Area
31.4Ų
Heavy Atom Count
16
Formal Charge
0
Complexity
257
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113321668-A | Synthesis of serpatatinib | 2021-06-21 |
| WO-2022032026-A1 | Compounds for targeted degradation of ret | 2020-08-05 |
| WO-2022026892-A1 | Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers | 2020-07-31 |
| CN-113620944-A | Novel RET inhibitors, pharmaceutical compositions thereof and uses thereof | 2020-05-07 |
| CN-113620945-A | RET inhibitor, pharmaceutical composition thereof and application thereof in medicines | 2020-05-07 |
| WO-2021213476-A1 | Pyrazolo[1,5-a]pyridine derivative, preparation method therefor, and composition and use thereof | 2020-04-22 |
| KR-102178181-B1 | Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof | 2020-03-31 |
| KR-20200076655-A | Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof | 2020-03-31 |
| WO-2021194326-A1 | Aminopyrimidine derivatives and their use as aryl hydrocarbon receptor modulators | 2020-03-27 |
| US-2021171535-A1 | Tricyclic heterocycles as fgfr inhibitors | 2019-12-04 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22263894 | 2012-03-08 | Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold | Journal of medicinal chemistry |
