6-Methoxy-2-(tributylstannyl)pyrimidine
Product Information
Molecular Formula
C17H32N2OSn
Molecular Weight
399.16
Description
6-Methoxy-2-(tributylstannyl)pyrimidine can be used as a reactant for the preparation of substituted pyrimidinone compounds via a Stille coupling reaction with aryl bromides. It can be also employed for the preparation of 4-methoxy-2-phenylpyrimidine by reacting with iodobenzene using Pd as a catalyst.
Synonyms
tributyl-(4-methoxypyrimidin-2-yl)stannane
IUPAC Name
tributyl-(4-methoxypyrimidin-2-yl)stannane
SMILES
CCCC[Sn](CCCC)(CCCC)C1=NC=CC(=N1)OC
InChI
InChI=1S/C5H5N2O.3C4H9.Sn/c1-8-5-2-3-6-4-7-5;3*1-3-4-2;/h2-3H,1H3;3*1,3-4H2,2H3;
InChI Key
HQUSEOSQVFRYQV-UHFFFAOYSA-N
Boiling Point
293 °C
Flash Point
Not applicable
Purity
95%
Density
1.164 g/mL at 25 °C
Refractive Index
n20/D 1.507
Safety Information
Hazards
H301 - H312 - H315 - H319 - H372 - H410
Precautionary Statement
P273 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P305 + P351 + P338 - P314
Computed Properties
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
11
Exact Mass
400.153666 g/mol
Monoisotopic Mass
400.153666 g/mol
Topological Polar Surface Area
35Ų
Heavy Atom Count
21
Formal Charge
0
Complexity
241
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2021064570-A1 | N-substututed-6-oxo-1,6-dihydropyrimidine-2-yl derivatives as inhibitors of the human immunodeficiency virus replication | 2019-10-01 |
| WO-2021064571-A1 | N-substituted-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl derivatives as inhibitors of the human immunodeficiency virus replication | 2019-10-01 |
| TW-201940481-A | GCN2 inhibitor and its use | 2018-01-29 |
| US-2019233411-A1 | Gcn2 inhibitors and uses thereof | 2018-01-29 |
| WO-2019148136-A1 | Gcn2 inhibitors and uses thereof | 2018-01-29 |
| AU-2019212969-A1 | GCN2 inhibitors and uses thereof | 2018-01-29 |
| CA-3089769-A1 | Gcn2 inhibitors and uses thereof | 2018-01-29 |
| CN-111867581-A | GCN2 inhibitors and uses thereof | 2018-01-29 |
| EP-3746071-A1 | Gcn2 inhibitors and uses thereof | 2018-01-29 |
| US-10793563-B2 | GCN2 inhibitors and uses thereof | 2018-01-29 |
