poly(vinylpyrrolidone)
Product Information
Molecular Formula
(C6H9NO)n
Description
Crospovidone is used as a drug excipient in drug formulations.
Synonyms
PVP; K-30; PVP-K; PVP-K30; PVP-K17; PVP-K25; PVP-K90
IUPAC Name
1-ethenylpyrrolidin-2-one
SMILES
C=CN1CCCC1=O
InChI
InChI=1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2
InChI Key
WHNWPMSKXPGLAX-UHFFFAOYSA-N
Boiling Point
217.6°C at 760 mmHg
Melting Point
130°C
Flash Point
93.9°C
Density
1.144g/cm3
Solubility
Soluble in chloroform (slightly), methanol (slightly).
Appearance
White to yellowish-white powder
Application
Used as a monomer in the production of polyvinyl pyrrolidone; also used in the production of other polymers and organic chemicals.
Storage
Room Temperature
Tg
120°C
Stability
Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
LogP
0.6902
Vapor Pressure
0.1 [mmHg]
Henry's Law Constant
5.5X10-8 atm-cu m/mol @ 25 °C /Estimated/
Decomposition
When heated to decomposition it emits toxic fumes of nitroxides. /Poly(1-vinyl-2-pyrrolidinone) homopolymer and Hueper's polymer 1-7/
Odor
ODORLESS
Safety Information
Hazards
Harmless-use normal precautions
Handling
Exercise normal care
QC Data
| Molecular Weight | Viscosity | Description |
|---|---|---|
| Mw 10000 | 1% AQ 1.21-1.28 cps | Water-soluble polymer used as a thickener, protective colloid. Tg~155℃ Polydispersity ~3.6 |
| Mw 2500 | 5% AQ 1.25-1.37 cps | Water-soluble polymer used as a thickener, protective colloid. Tg~90℃. Polydispersity ~1.9 |
| Mw 40000 | 1% AQ 3.65 cps | Pharmaceutical grade. Tg~168℃ |
| Mw 1000000 | 1% AQ 4.90 cp | Water-soluble polymer used as a thickener, protective colloid. Tg>175℃ Polydispersity ~2.00 |
Computed Properties
XLogP3
0.4
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
1
Exact Mass
111.068413911 g/mol
Monoisotopic Mass
111.068413911 g/mol
Topological Polar Surface Area
20.3Ų
Heavy Atom Count
8
Formal Charge
0
Complexity
120
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| EP-3818972-A2 | Piroctone olamine granules for use in cosmetic compositions | 2021-01-29 |
| US-2021007978-A1 | Fixed Dose Oral Testosterone Undecanoate Compositions and Use Thereof | 2020-09-25 |
| US-11033516-B1 | Combination therapies with disulfiram | 2020-09-18 |
| US-11028300-B1 | Environmentally friendly refrigerant compositions | 2020-09-16 |
| US-10858566-B2 | Drilling fluid with improved fluid loss and viscosifying properties | 2020-04-14 |
| US-2020255716-A1 | Drilling fluid with improved fluid loss and viscosifying properties | 2020-04-14 |
| US-11045434-B1 | Niclosamide formulations for treating disease | 2020-04-01 |
| US-11007134-B1 | Ceramide containing capsules, ceramide compositions, and cosmetic compositions thereof | 2020-03-31 |
| EP-3799848-A1 | Absorbent articles and methods of making | 2020-03-19 |
| EP-3677244-A2 | Compositions comprising multilamellar vesicles | 2020-02-04 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 34595563 | 2021-12-01 | Enigmatic mechanism of the N-vinylpyrrolidone hepatocarcinogenicity in the rat | Archives of toxicology |
| 22800730 | 2012-12-01 | Synthesis of gum kondagogu-g-poly(N-vinyl-2-pyrrolidone) and its evaluation as a mucoadhesive polymer | International journal of biological macromolecules |
| 22590998 | 2012-11-01 | Does vaginal preparation with povidone-iodine prior to caesarean delivery reduce the risk of endometritis? A randomized controlled trial | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians |
| 23079318 | 2012-11-01 | Bilateral Fusarium oxysporum keratitis after laser in situ keratomileusis | Journal of cataract and refractive surgery |
| 23090520 | 2012-11-01 | Chlorhexidine-alcohol compared with povidone-iodine for surgical-site antisepsis in cesarean deliveries | Obstetrics and gynecology |
| 22705046 | 2012-10-01 | Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(D,L-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins | Acta biomaterialia |
| 22797354 | 2012-10-01 | A multicentre analysis of catheter-related infection based on a hierarchical model | Intensive care medicine |
| 22909110 | 2012-10-01 | Low-cost periodontal therapy | Periodontology 2000 |
| 22964685 | 2012-10-01 | Evidence-based protocol for infection control in immediate implant-based breast reconstruction | Annals of plastic surgery |
| 22891651 | 2012-09-11 | In situ monitoring of Pt nanoparticle formation in ethylene glycol solution by SAXS-influence of the NaOH to Pt ratio | Langmuir : the ACS journal of surfaces and colloids |
