Cyclopentyl methyl ether
Product Information
Molecular Formula
C6H12O
Molecular Weight
100.16
Description
• Cyclopentyl methyl ether (CPME) is an alternative to ether solvents such as THF, diethyl ether, and MTBE with a higher resistance to peroxide formation.• The more environmentally conservative CPME solvent replaces hazardous solvents in order to achieve sustainability and reduce environmental and operational costs.• CPME offers considerable potential and advantage as a direct replacement for CH2Cl2 in binary eluents using MeOH as the modifier with MeOH-DMC and i-PrOH-EtOAc.
Green Alternative to THF, tert-Butyl methyl ether (MTBE), 1,4 Dioxane and other ether solventsThe toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.
Green Alternative to THF, tert-Butyl methyl ether (MTBE), 1,4 Dioxane and other ether solventsThe toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.
Synonyms
CYCLOPENTYL METHYL ETHER; METHOXYCYCLOPENTANE; Cyclopentyl methyl ether, ReagentPlus(R), >=99.90%; Cyclopentyl methyl ether, anhydrous, >=99.9%; CYCLOPENTYL METHYL ETHER, WITH STABILIZER; Cyclopentyl methyl ether, 99.9+%
IUPAC Name
methoxycyclopentane
SMILES
COC1CCCC1
InChI
InChI=1S/C6H12O/c1-7-6-4-2-3-5-6/h6H,2-5H2,1H3
InChI Key
SKTCDJAMAYNROS-UHFFFAOYSA-N
Boiling Point
106°C
Melting Point
-140°C
Flash Point
30.2 °F - closed cup
Purity
95%
Density
0.86
Storage
Flammables area
Safety Information
Hazards
H225 - H302 - H315 - H319 - H412
Precautionary Statement
P210 - P301 + P312 + P330 - P305 + P351 + P338 - P370 + P378 - P403 + P235
Computed Properties
XLogP3
1.3
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
1
Exact Mass
100.088815002 g/mol
Monoisotopic Mass
100.088815002 g/mol
Topological Polar Surface Area
9.2Ų
Heavy Atom Count
7
Formal Charge
0
Complexity
46.1
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114181189-A | Method for purifying cyclic lactide | 2021-12-16 |
| JP-2022037094-A | Method for producing a polyene compound having a hydroxyl group | 2021-12-14 |
| CN-114106043-A | Compound, preparation method thereof, method for preparing citicoline by compound and application | 2021-12-06 |
| CN-114105882-A | Imidazole structure group-based isocyanate electrolyte additive and application thereof | 2021-11-24 |
| CN-113980250-A | Conjugated polymer material capable of being processed by green solvent and preparation method thereof | 2021-11-20 |
| CN-113845692-A | Polycarbosilane/phenolic aldehyde dual-system network structure aerogel and composite material and preparation method thereof | 2021-11-19 |
| CN-113979855-A | Preparation method of crotonic acid | 2021-11-17 |
| CN-113801033-A | Synthesis method of 2-aminoindan or derivatives thereof | 2021-11-16 |
| CN-113801033-B | Synthesis method of 2-aminoindan or derivatives thereof | 2021-11-16 |
| CN-114105822-A | Pseudo C2Symmetrical chiral diallyl substituted compound and preparation method and application thereof | 2021-11-16 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22699568 | 2012-06-14 | Ring-expansion reaction of oximes with aluminum reductants | Molecules (Basel, Switzerland) |
| 21337529 | 2011-04-18 | Cyclopentyl methyl ether: an alternative solvent for palladium-catalyzed direct arylation of heteroaromatics | ChemSusChem |
| 19323570 | 2009-04-03 | Recycling the tert-butanesulfinyl group in the synthesis of amines using tert-butanesulfinamide | The Journal of organic chemistry |
| 18493644 | 2008-06-01 | 2-Methoxycyclopentyl analogues of a Pseudomonas aeruginosa quorum sensing modulator | Molecular bioSystems |
| 17877405 | 2007-10-12 | Practical and robust method for regio- and stereoselective preparation of (E)-ketene tert-butyl TMS acetals and beta-ketoester-derived tert-butyl (1Z,3E)-1,3-bis(TMS)dienol ethers | The Journal of organic chemistry |
| 15810842 | 2005-04-13 | Highly enantioselective phase-transfer-catalyzed alkylation of protected alpha-amino acid amides toward practical asymmetric synthesis of vicinal diamines, alpha-amino ketones, and alpha-amino alcohols | Journal of the American Chemical Society |
| 15834802 | 2005-03-01 | Enhancement of enzyme activity and enantioselectivity by cyclopentyl methyl ether in the transesterification catalyzed by Pseudomonas cepacia lipase co-lyophilized with cyclodextrins | Biotechnology letters |
