DTPA dianhydride
Product Information
Molecular Formula
C14H19N3O8
Molecular Weight
357.32
Description
DTPA dianhydride is a multifaceted compound of immense significance and finds extensive application within the realm of biomedicine. Prominently employed as a pivotal constituent in pharmaceutical formulations, this compound exhibits remarkable efficacy when combatting diverse afflictions encompassing cancer, diabetes, and neurological disorders. Its pharmacological potential propels it to the forefront of drug discovery and therapeutic interventions, solidifying its indispensable status within the realm of biomedicine.
Synonyms
Diethylenetriaminepentaacetic dianhydride; Cdtpaa; Cyclic dtpa anhydride; Dtpa cyclic anhydride
IUPAC Name
2-[bis[2-(2,6-dioxomorpholin-4-yl)ethyl]amino]acetic acid
SMILES
C1C(=O)OC(=O)CN1CCN(CCN2CC(=O)OC(=O)C2)CC(=O)O
InChI
InChI=1S/C14H19N3O8/c18-10(19)5-15(1-3-16-6-11(20)24-12(21)7-16)2-4-17-8-13(22)25-14(23)9-17/h1-9H2,(H,18,19)
InChI Key
RAZLJUXJEOEYAM-UHFFFAOYSA-N
Boiling Point
656.2°C at 760 mmHg
Melting Point
190-184°C
Purity
>98.0%(T)
Density
1.46g/cm3
Appearance
white or cream white solid
Storage
−20°C
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Computed Properties
XLogP3
-3.3
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
11
Rotatable Bond Count
8
Exact Mass
357.11721457 g/mol
Monoisotopic Mass
357.11721457 g/mol
Topological Polar Surface Area
134Ų
Heavy Atom Count
25
Formal Charge
0
Complexity
504
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114042439-A | Uranium-containing wastewater adsorbent and preparation method thereof | 2021-12-15 |
| CN-113209304-A | Chelated calcium self-assembled nano particle and preparation method and application thereof | 2021-05-19 |
| CN-113234442-A | Paramagnetic chiral graphene quantum dot and preparation method and application thereof | 2021-05-11 |
| CN-113509562-A | Formulations comprising PD-L1 binding polypeptide compositions and methods of making the same | 2021-04-22 |
| CN-113057411-A | Anti-skid shoe sole for women and preparation process of anti-skid shoe sole | 2021-04-13 |
| CN-112741837-A | Brain-targeting nano-drug delivery system and preparation method thereof | 2020-12-03 |
| CN-112741837-B | Brain-targeting nano-drug delivery system and preparation method thereof | 2020-12-03 |
| CN-112480151-A | Novel fluorescent probe, preparation method thereof and application of novel fluorescent probe in detection of sulfadimidine in honey | 2020-11-25 |
| CN-112221539-A | Catalyst for hydrosilylation reaction and preparation method and application thereof | 2020-11-17 |
| CN-112457797-A | High-temperature-resistant cyanate ester conductive adhesive and preparation method thereof | 2020-10-27 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22709587 | 2012-08-20 | Hyaluronic acid-ceramide-based optical/MR dual imaging nanoprobe for cancer diagnosis | Journal of controlled release : official journal of the Controlled Release Society |
| 21922111 | 2011-12-01 | Stability assessment of different chelating moieties used for elemental labeling of bio-molecules | Metallomics : integrated biometal science |
| 20592929 | 2010-07-01 | Visualization of tumor angiogenesis using MR imaging contrast agent Gd-DTPA-anti-VEGF receptor 2 antibody conjugate in a mouse tumor model | Korean journal of radiology |
| 19919931 | 2009-12-01 | Development of a radiolabeled beta-human chorionic gonadotropin | Acta pharmaceutica (Zagreb, Croatia) |
| 17785729 | 2007-09-01 | Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer | Journal of nuclear medicine : official publication, Society of Nuclear Medicine |
| 16102904 | 2005-10-10 | Synthesis and characterization of a novel DTPA polymerized hemoglobin based oxygen carrier | Biochimica et biophysica acta |
| 12433040 | 2002-11-01 | Labeling of monoclonal antibodies with 153Sm for potential use in radioimmunotherapy | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine |
| 10628656 | 1999-12-01 | Charge modification of plasma and milk proteins results in antiviral active compounds | Journal of peptide science : an official publication of the European Peptide Society |
