DTPA dianhydride
Product Information
Molecular Formula
C14H19N3O8
Molecular Weight
357.32
Description
DTPA dianhydride is a bifunctional chelator (BFC) used as a contrast agent. DTPA dianhydride can bind to peptides, proteins as well as radionuclides to synthesize radionuclide-labeled drug conjugates (RDCs).
Synonyms
Diethylenetriaminepentaacetic dianhydride; Cdtpaa; Cyclic dtpa anhydride; Dtpa cyclic anhydride
IUPAC Name
2-[bis[2-(2,6-dioxomorpholin-4-yl)ethyl]amino]acetic acid
SMILES
C1C(=O)OC(=O)CN1CCN(CCN2CC(=O)OC(=O)C2)CC(=O)O
InChI
InChI=1S/C14H19N3O8/c18-10(19)5-15(1-3-16-6-11(20)24-12(21)7-16)2-4-17-8-13(22)25-14(23)9-17/h1-9H2,(H,18,19)
InChI Key
RAZLJUXJEOEYAM-UHFFFAOYSA-N
Boiling Point
656.2°C at 760 mmHg
Melting Point
190-184°C
Purity
>98.0%(T)
Density
1.46g/cm3
Appearance
white or cream white solid
Storage
−20°C
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].
Computed Properties
XLogP3
-3.3
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
11
Rotatable Bond Count
8
Exact Mass
357.11721457 g/mol
Monoisotopic Mass
357.11721457 g/mol
Topological Polar Surface Area
134Ų
Heavy Atom Count
25
Formal Charge
0
Complexity
504
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114042439-A | Uranium-containing wastewater adsorbent and preparation method thereof | 2021-12-15 |
| CN-113209304-A | Chelated calcium self-assembled nano particle and preparation method and application thereof | 2021-05-19 |
| CN-113234442-A | Paramagnetic chiral graphene quantum dot and preparation method and application thereof | 2021-05-11 |
| CN-113509562-A | Formulations comprising PD-L1 binding polypeptide compositions and methods of making the same | 2021-04-22 |
| CN-113057411-A | Anti-skid shoe sole for women and preparation process of anti-skid shoe sole | 2021-04-13 |
| CN-112741837-A | Brain-targeting nano-drug delivery system and preparation method thereof | 2020-12-03 |
| CN-112741837-B | Brain-targeting nano-drug delivery system and preparation method thereof | 2020-12-03 |
| CN-112480151-A | Novel fluorescent probe, preparation method thereof and application of novel fluorescent probe in detection of sulfadimidine in honey | 2020-11-25 |
| CN-112221539-A | Catalyst for hydrosilylation reaction and preparation method and application thereof | 2020-11-17 |
| CN-112457797-A | High-temperature-resistant cyanate ester conductive adhesive and preparation method thereof | 2020-10-27 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22709587 | 2012-08-20 | Hyaluronic acid-ceramide-based optical/MR dual imaging nanoprobe for cancer diagnosis | Journal of controlled release : official journal of the Controlled Release Society |
| 21922111 | 2011-12-01 | Stability assessment of different chelating moieties used for elemental labeling of bio-molecules | Metallomics : integrated biometal science |
| 20592929 | 2010-07-01 | Visualization of tumor angiogenesis using MR imaging contrast agent Gd-DTPA-anti-VEGF receptor 2 antibody conjugate in a mouse tumor model | Korean journal of radiology |
| 19919931 | 2009-12-01 | Development of a radiolabeled beta-human chorionic gonadotropin | Acta pharmaceutica (Zagreb, Croatia) |
| 17785729 | 2007-09-01 | Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer | Journal of nuclear medicine : official publication, Society of Nuclear Medicine |
| 16102904 | 2005-10-10 | Synthesis and characterization of a novel DTPA polymerized hemoglobin based oxygen carrier | Biochimica et biophysica acta |
| 12433040 | 2002-11-01 | Labeling of monoclonal antibodies with 153Sm for potential use in radioimmunotherapy | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine |
| 10628656 | 1999-12-01 | Charge modification of plasma and milk proteins results in antiviral active compounds | Journal of peptide science : an official publication of the European Peptide Society |
