Guaiacol glycidyl ether
Product Information
Molecular Formula
C10H12O3
Molecular Weight
180.20
Description
1-(2,3-Epoxypropoxy)-2-methoxybenzene is one of Ranolazine intermediates. Ranolazine is an anti-ischemic agent which modulates myocardial metabolism.
Synonyms
1,2-Epoxy-3-(2-methoxyphenoxy)propane; 1,2-Epoxy-3-(o-methoxyphenoxy)propane; Glycidyl 2-Methoxyphenyl Ether; 1-(2-Methoxyphenoxy)-2,3-epoxypropane; NSC 112256; NSC 133442; Guaiacol glycidyl ether; Methoxyphenyl glycidyl ether; Ranolazine Impurity 6; Ranolazine USP Related Compound A
IUPAC Name
2-[(2-methoxyphenoxy)methyl]oxirane
SMILES
COC1=CC=CC=C1OCC2CO2
InChI
InChI=1S/C10H12O3/c1-11-9-4-2-3-5-10(9)13-7-8-6-12-8/h2-5,8H,6-7H2,1H3
InChI Key
RJNVSQLNEALZLC-UHFFFAOYSA-N
Boiling Point
152-158°C
Melting Point
33-36°C
Purity
96%
Density
1.142±0.06 g/cm3 (Predicted)
Solubility
Soluble in Chloroform, Methanol
Appearance
White to Off-white Low-melting Solid
Storage
Store at -20°C
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
H341:
Suspected of causing genetic defects.
Causes skin irritation.
H319:
Causes serious eye irritation.
H341:
Suspected of causing genetic defects.
Precautionary Statement
P201:
Obtain special instructions before use.
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:
If exposed or concerned:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Obtain special instructions before use.
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:
If exposed or concerned:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Computed Properties
XLogP3
1.6
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
4
Exact Mass
180.078644241 g/mol
Monoisotopic Mass
180.078644241 g/mol
Topological Polar Surface Area
31Ų
Heavy Atom Count
13
Formal Charge
0
Complexity
160
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113387873-A | Substituted diaryl compound, preparation method and application thereof | 2021-06-15 |
| WO-2022049070-A1 | Electrically conductive epoxy resin coating and electrostatically dissipative floor | 2020-09-01 |
| WO-2022049071-A1 | Transparent electrically conductive epoxy resin coating and electrostatic dissipative floor | 2020-09-01 |
| CN-111440131-A | Method for refining easy-to-decompose guaiacol glycidyl ether | 2020-04-27 |
| CN-111440131-B | Method for refining easy-to-decompose guaiacol glycidyl ether | 2020-04-27 |
| WO-2021170511-A1 | Amine epoxy resin adduct | 2020-02-24 |
| WO-2021170512-A1 | Amine-epoxy resin addition product | 2020-02-24 |
| WO-2021170513-A1 | Curing agents for epoxy resin coatings | 2020-02-24 |
| CN-113045934-A | Printing ink, application thereof and preparation method of quantum dot film | 2019-12-28 |
| WO-2021083744-A1 | Impregnation resin for a woven or stitched fabric | 2019-10-28 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 5832 | 1975-01-01 | [Effect of a new beta-sympatholytic agent for ICI 66 082 on hemodynamics and cardiac contraction without and with experimental coronary occlusion] | Verhandlungen der Deutschen Gesellschaft fur Innere Medizin |
