Hydroxyethyl cellulose
Product Information
Description
Hydroxyethyl cellulose is a non-ionic, water-soluble polysaccharide derived from cellulose, presented as a fine, free-flowing powder. Its unique hydroxyethyl substituents enhance solubility and viscosity modulation, making it valuable for studies involving rheology and polymer interactions. The compound exhibits excellent stability across a wide pH range, supporting its use in diverse biochemical and biotechnological research settings. Frequently employed to investigate gel formation, encapsulation, and as a matrix in controlled-release experiments, hydroxyethyl cellulose is integral to advanced laboratory and formulation research.
Synonyms
Cellulose, 2-hydroxyethyl ether; Cellulose hydroxyethylate; 2-Hydroxyethyl cellulose; 2-Hydroxyethyl cellulose ether; Alcoramnosan; Cellulose hydroxyethyl ether; Hydroxyethyl cellulose ether; Hydroxyethyl ether cellulose; Hyetellose; Liporamnosan; Sanhec
Melting Point
140 °C
Flash Point
725 °F
Density
0.6 g/cm3
Solubility
Soluble in Water
Appearance
White to off-white powder
Application
·Used as adhesives, bonding aids, filling cement admixtures
·Used as coatings and optical brightener additives, coating polymers, filter control additives
·Used as wet strength enhancer, protective colloid, rebound and slip reducing agent, rheology control modifier
·Used as a gelling and thickening agent in the development of biological structures for hydrophobic drugs
·Used as coatings and optical brightener additives, coating polymers, filter control additives
·Used as wet strength enhancer, protective colloid, rebound and slip reducing agent, rheology control modifier
·Used as a gelling and thickening agent in the development of biological structures for hydrophobic drugs
Storage
Store at -20 °C
Grade
Reagent Grade
Stability
Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides
LogP
0.35240
Safety Information
Hazards
Irritant
Handling
Gloves & fume hood
| Molecular Weight | Viscosity | Description |
|---|---|---|
| ~1,000,000 | 1% AQ = 1.500-2.500 cps | Water-soluble cellulose ether, used as a binder and thickening agent. Powder |
| ~90,000 | 5% AQ = 75-150 cps | Water-soluble cellulose ether, used as a binder and thickening agent. Powder |
| ~720,000 | 2% AQ = 4.500-6.500 cps | Water-soluble cellulose ether, used as a binder and thickening agent. Powder |
Computed Properties
XLogP3
-7.7
Hydrogen Bond Donor Count
11
Hydrogen Bond Acceptor Count
21
Rotatable Bond Count
15
Exact Mass
736.30010866 g/mol
Monoisotopic Mass
736.30010866 g/mol
Topological Polar Surface Area
315Ų
Heavy Atom Count
50
Formal Charge
0
Complexity
999
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
20
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2021086938-A1 | Drip-free cleansing mask with enhanced active deposition | 2019-10-30 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 25735667 | 2015-04-30 | Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application | International journal of pharmaceutics |
| 22795045 | 2012-10-01 | Phase behavior and rheological properties of DNA-cationic polysaccharide mixtures | Journal of colloid and interface science |
| 22840013 | 2012-10-01 | A versatile method for functionalization and grafting of 2-hydroxyethyl cellulose (HEC) via Click chemistry | Carbohydrate polymers |
| 22840022 | 2012-10-01 | Preparation and characterization of poly(acrylic acid)-hydroxyethyl cellulose graft copolymer | Carbohydrate polymers |
| 22360941 | 2012-08-15 | Development of liposome gel based formulations for intravaginal delivery of the recombinant HIV-1 envelope protein CN54gp140 | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences |
| 22594324 | 2012-05-01 | Enhanced viability of corneal epithelial cells for efficient transport/storage using a structurally modified calcium alginate hydrogel | Regenerative medicine |
| 22448630 | 2012-04-10 | Dispersions of nanocrystalline cellulose in aqueous polymer solutions: structure formation of colloidal rods | Langmuir : the ACS journal of surfaces and colloids |
| 22155401 | 2012-04-01 | Concentration selective hydration and phase states of hydroxyethyl cellulose (HEC) in aqueous solutions | International journal of biological macromolecules |
| 22310278 | 2012-03-16 | Is pulsed electric field still effective for RNA separation in capillary electrophoresis? | Journal of chromatography. A |
| 21895999 | 2012-03-01 | Effects of cationic hydroxyethyl cellulose on glucose metabolism and obesity in a diet-induced obesity mouse model | Journal of diabetes |
