Methyl gallate
Product Information
Molecular Formula
C8H8O5
Molecular Weight
184.15
Description
Methyl gallate isolated from the herbs of Sapium sebiferum. It is a reverse transcriptase inhibitor.
Synonyms
Methyl 3,4,5-trihydroxybenzoate; 3,4,5-trihydroxy-benzoicacimethylester
IUPAC Name
methyl 3,4,5-trihydroxybenzoate
SMILES
COC(=O)C1=CC(=C(C(=C1)O)O)O
InChI
InChI=1S/C8H8O5/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,9-11H,1H3
InChI Key
FBSFWRHWHYMIOG-UHFFFAOYSA-N
Boiling Point
450.1±40.0 °C at 760 mmHg
Melting Point
201-203 °C (lit.)
Flash Point
190.8±20.8 °C
Purity
0.98
Density
1.5±0.1 g/cm3
Solubility
In vitro:
10 mM in DMSO
10 mM in DMSO
Appearance
Powder
Application
Used as an antioxidant.
Storage
Powder:
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month
-20°C: 3 years
4°C: 2 years
In solvent:
-80°C: 6 months
-20°C: 1 month
Vapor Pressure
0.0±1.1 mmHg at 25°C
Safety Information
Hazards
H302 - H315 - H319 - H335
Precautionary Statement
P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
Computed Properties
XLogP3
0.9
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Rotatable Bond Count
2
Exact Mass
184.03717335 g/mol
Monoisotopic Mass
184.03717335 g/mol
Topological Polar Surface Area
87Ų
Heavy Atom Count
13
Formal Charge
0
Complexity
181
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114099522-A | 1,2,3,4, 6-O-pentagalloyl glucose used as serine protease inhibitor, screening method and application | 2021-11-24 |
| CN-113980858-A | Lactobacillus plantarum YL399 for producing high-activity tannase and application thereof in preparation of codonopsis pilosula fermented feed | 2021-11-18 |
| CN-113999144-A | Amphiphilic molecular compound, preparation method and amphiphilic nano material | 2021-11-18 |
| CN-114085241-A | Probe for detecting and identifying tea polyphenol and preparation method and application thereof | 2021-11-18 |
| CN-113980485-A | Biological enzyme compound and method for applying biological enzyme compound to plant extraction process | 2021-11-16 |
| CN-113862000-A | Liquid crystal polymer with continuously adjustable fluorescence color and preparation method thereof | 2021-11-09 |
| CN-113973999-A | Fermented compound traditional Chinese medicine additive for improving sow amniotic fluid volume and PSY and preparation method thereof | 2021-10-27 |
| CN-114099488-A | Application of gallic acid or its derivative in inducing differentiation and proliferation of neural stem cell | 2021-10-13 |
| CN-113917031-A | Method for determining blood concentration of lung-tonifying and blood-activating capsule in vivo by UHPLC-MS/MS method | 2021-10-12 |
| CN-113728776-A | Balanced fertilization method for landscaping goldenrain tree | 2021-09-28 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 32112863 | 2020-04-01 | Methyl gallate: Selective antileishmanial activity correlates with host-cell directed effects | Chemico-biological interactions |
| 27777014 | 2016-12-25 | Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells | Chemico-biological interactions |
| 23684720 | 2013-07-09 | Antimicrobial activity of Schinus lentiscifolius (Anacardiaceae) | Journal of ethnopharmacology |
| 22891951 | 2012-09-12 | Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori | Journal of agricultural and food chemistry |
| 22144737 | 2012-09-01 | Antimetastatic potentials of Phyllanthus urinaria L on A549 and Lewis lung carcinoma cells via repression of matrix-degrading proteases | Integrative cancer therapies |
| 22277734 | 2012-05-01 | Isolation and characterization of ellagitannins as the major polyphenolic components of Longan (Dimocarpus longan Lour) seeds | Phytochemistry |
| 22490328 | 2012-04-10 | A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line | BMC complementary and alternative medicine |
| 22538659 | 2012-04-01 | Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro | Journal of microbiology (Seoul, Korea) |
| 22447026 | 2012-03-23 | Screening of anti-obesity agent from herbal mixtures | Molecules (Basel, Switzerland) |
| 22082098 | 2012-03-01 | Anti-inflammatory activity of Pistacia khinjuk in different experimental models: isolation and characterization of its flavonoids and galloylated sugars | Journal of medicinal food |
