Poly(3-hydroxybutyric acid)
Product Information
Description
3-hydroxybutyric acid is a straight-chain 3-hydroxy monocarboxylic acid comprising a butyric acid core with a single hydroxy substituent in the 3- position; a ketone body whose levels are raised during ketosis, used as an energy source by the brain during fasting in humans. Also used to synthesise biodegradable plastics. It has a role as a human metabolite. It is a 3-hydroxy monocarboxylic acid, a hydroxybutyric acid and an (omega-1)-hydroxy fatty acid. It is functionally related to a butyric acid. It is a conjugate acid of a 3-hydroxybutyrate.
Synonyms
POLY(3-HYDROXYBUTYRATE); POLY(3-HYDROXYBUTYRATE) OLIGOMER; POLY(3-HYDROXYBUTYRIC ACID); POLY[(-)3-HYDROXYBUTYRIC ACID]; poly-beta-hydroxybutyrate; POLY(3-HYDROXYBUTYRIC ACID), NATURAL ORI GIN; Poly(3-hydroxyvalericacid); 3-hydroxybutyric acid homopolymer
Density
1.195 g/cm3
Application
Ketone produced in the liver.
Storage
Store at room temperature
Tg
15°
Safety Information
Hazards
Harmless-use normal precautions
Handling
Exercise normal care
| Molecular Weight | Description |
|---|---|
| Mw ~500,000 | Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance. |
| Mw ~2000 | Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance. |
| Mw ~5000 | Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance. |
| Mw ~3000 | Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance. |
| Mw ~500 | Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance. |
| Mw ~1000 | Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance. |
| Mw ~10,000 | Tm is 168-176°. The biodegradable and non-toxic effect of PHBs make them a strong possibility for many medical applications, including drug release, bone regeneration and nerve guidance. |
Computed Properties
XLogP3
-0.5
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
2
Exact Mass
104.047344113 g/mol
Monoisotopic Mass
104.047344113 g/mol
Topological Polar Surface Area
57.5Ų
Heavy Atom Count
7
Formal Charge
0
Complexity
69.3
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114134096-A | 3-hydroxybutyrate, 4-hydroxybutyrate and 3-hydroxyvalerate terpolymer P (3HB-4HB-3HV) and microbial production thereof | 2022-02-07 |
| CN-114134095-A | Method for producing L-lysine and/or 1, 5-pentanediamine by using halophilic bacteria | 2022-01-28 |
| CN-114166977-A | System for predicting blood glucose value of pregnant individual | 2022-01-24 |
| CN-114167066-A | Application of biomarker in preparation of gestational diabetes diagnosis reagent | 2022-01-24 |
| CN-114031760-A | High-barrier-property high-strength PBAT-PGA (poly (butylene adipate-co-terephthalate) -poly (propylene glycol)) block copolymer biodegradable polyester and preparation method thereof | 2022-01-07 |
| CN-113999869-A | Promoter with expression intensity regulated by synthesis of bacterial intracellular Polyhydroxyalkanoate (PHA) and application thereof | 2021-12-31 |
| JP-2022037181-A | A method for producing a chemically amplified photosensitive composition, a photosensitive dry film, and a method for producing a patterned resist film. | 2021-12-22 |
| CN-113929762-A | 3-hydroxybutyrylated and/or 3-hydroxypentylglycolylated modified insulin and application thereof | 2021-12-16 |
| CN-114058221-A | Water-based high-wear-resistance high-hardness high-scratch-resistance core-shell structure wax emulsion and preparation method thereof | 2021-12-16 |
| CN-114149604-A | Near-infrared light response type slow-release composite packaging film and preparation method and application thereof | 2021-12-15 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 32634519 | 2020-09-01 | Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells | Toxicology and applied pharmacology |
| 31332890 | 2019-09-01 | β-Hydroxybutyrate exacerbates lipopolysaccharide/ d-galactosamine-induced inflammatory response and hepatocyte apoptosis in mice | Journal of biochemical and molecular toxicology |
| 29968805 | 2018-07-03 | Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics | Scientific reports |
| 29738703 | 2018-06-01 | High fat diet induced obesity is mitigated in Cyp3a-null female mice | Chemico-biological interactions |
| 27816970 | 2017-04-04 | HMGCS2 enhances invasion and metastasis via direct interaction with PPARα to activate Src signaling in colorectal cancer and oral cancer | Oncotarget |
| 27481192 | 2016-09-25 | 1'-Acetoxychavicol acetate ameliorates age-related spatial memory deterioration by increasing serum ketone body production as a complementary energy source for neuronal cells | Chemico-biological interactions |
| 25943029 | 2015-08-01 | Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway | Molecular nutrition & food research |
| 25686106 | 2015-03-01 | The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease | Nature medicine |
| 25440059 | 2014-11-04 | A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome | Cell metabolism |
| 22687249 | 2012-11-30 | Artificial microRNA-mediated knockdown of pyruvate formate lyase (PFL1) provides evidence for an active 3-hydroxybutyrate production pathway in the green alga Chlamydomonas reinhardtii | Journal of biotechnology |
