Propylene glycol
Product Information
Molecular Formula
C3H8O2
Molecular Weight
76.095
Description
Propylene glycol can be used as a solvent in oral and topical drug products.
Synonyms
1,2-Propanediol
IUPAC Name
propane-1,2-diol
SMILES
CC(CO)O
InChI
InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3
InChI Key
DNIAPMSPPWPWGF-UHFFFAOYSA-N
Boiling Point
188 °C
Melting Point
-59 °C
Flash Point
107 °C
Purity
>99.0%(GC)
Density
1.036 g/mL at 25°C(lit.)
Solubility
Soluble in chloroform (slightly), ethyl acetate (slightly), methanol (slightly).
Appearance
Colourless Oil
Application
Used in antifreeze and deicing solutions for cars, boats, and aircraft; also used as a solvent for paints and plastics and to create harmless, artificial smoke for training and theatrical purposes.
Storage
Room Temperature
Refractive Index
n20/D 1.432(lit.)
Stability
Stable under normal temperatures and pressures.
LogP
-0.64050
Vapor Pressure
0.08 mmHg at 68 °F
Henry's Law Constant
1.3X10-8 atm-cu m/mol at 25 °C (est)
Decomposition
When heated to decomposition it emits acrid smoke and irritating fumes.
Dissociation Constants
14.9
Odor
Practically odorless
Safety Information
Hazards
H319:
Causes serious eye irritation.
Causes serious eye irritation.
Precautionary Statement
P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:
IF IN EYES:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do. Continue rinsing.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:
IF IN EYES:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do. Continue rinsing.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
Computed Properties
XLogP3
-0.9
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
1
Exact Mass
76.052429494 g/mol
Monoisotopic Mass
76.052429494 g/mol
Topological Polar Surface Area
40.5Ų
Heavy Atom Count
5
Formal Charge
0
Complexity
20.9
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-109833832-A | A kind of axis radial direction HPPO fixed bed reactors | 2019-04-08 |
| CN-109942512-A | A method of propylene oxide is prepared with microchannel hybrid system processing propylene-dioxygen water-methanol solution | 2019-04-08 |
| CN-109912542-A | A kind of method that the homogeneous system of low propylene usage amount prepares propylene oxide | 2019-03-28 |
| CN-109180611-A | A kind of HPPO method of raw material segmentation injection prepares the device and method of propylene oxide | 2018-10-12 |
| CN-108348520-A | MDM2 inhibitor and a combination thereof | 2015-08-28 |
| US-2016089439-A1 | Prevention of Illicit Manufacutre of Methamphetamine from Pseudoephedrine Using Food Flavor Excipients | 2014-09-28 |
| US-2016168190-A1 | C-20 steroid compounds, compositions and uses thereof to treat traumatic brain injury (tbi), including concussions | 2014-09-17 |
| US-2016053058-A1 | Polyester polyols from recycled polymers and waste streams | 2014-08-20 |
| US-2015017229-A1 | Method and system for synthesizing nanocarrier based long acting drug delivery system for insulin | 2014-07-21 |
| US-2015024034-A1 | Method and system for synthesizing nanocarrier based long acting drug delivery system for dexamethasone | 2014-07-21 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 29432853 | 2018-03-01 | Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio) | Neurotoxicology |
| 28065790 | 2017-12-01 | Comparison of cellular and transcriptomic effects between electronic cigarette vapor and cigarette smoke in human bronchial epithelial cells | Toxicology in vitro : an international journal published in association with BIBRA |
| 25959454 | 2016-01-01 | Safety data on 19 vehicles for use in 1 month oral rodent pre-clinical studies: administration of hydroxypropyl-ß-cyclodextrin causes renal toxicity | Journal of applied toxicology : JAT |
| 22296239 | 2012-11-01 | A comparative study of vitamin E TPGS/HPMC supersaturated system and other solubilizer/polymer combinations to enhance the permeability of a poorly soluble drug through the skin | Drug development and industrial pharmacy |
| 22681227 | 2012-11-01 | Treatment of distal subungual onychomycosis with a topical preparation of urea, propylene glycol and lactic acid: results of a 24-week, double-blind, placebo-controlled study | Mycoses |
| 23051026 | 2012-11-01 | Novel double phase transforming organogel based on β-cyclodextrin in 1,2-propylene glycol | The journal of physical chemistry. B |
| 22641171 | 2012-10-05 | The propylene glycol research project to illustrate the feasibility and difficulties to study toxicokinetics in neonates | International journal of pharmaceutics |
| 22841658 | 2012-10-05 | Intrathecal dihydroergotamine inhibits capsaicin-induced vasodilatation in the canine external carotid circulation via GR127935- and rauwolscine-sensitive receptors | European journal of pharmacology |
| 22619090 | 2012-10-01 | Sustained delivery of paclitaxel using thermogelling poly(PEG/PPG/PCL urethane)s for enhanced toxicity against cancer cells | Journal of biomedical materials research. Part A |
| 22967518 | 2012-09-15 | A simple strategy to monitor lipase activity using liquid crystal-based sensors | Talanta |
