Sodium stearate

Product Information

Molecular Formula:
C18H35NaO2
Molecular Weight:
306.466
Description
Sodium stearate is used as a surfactant to aid the solubility of hydrophobic compounds in the pharmaceutical industry.
Synonyms
Stearic acid, sodium salt
IUPAC Name
sodiumoctadecanoate
Canonical SMILES
CCCCCCCCCCCCCCCCCC(=O)[O-].[Na+]
InChI
InChI=1S/C18H36O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2-17H2,1H3,(H,19,20);/q;+1/p-1
InChI Key
RYYKJJJTJZKILX-UHFFFAOYSA-M
Melting Point
220 °C
Flash Point
162.4°C
Purity
>97.0%(T)
Density
1.103 g/cm³
Solubility
SLOWLY SOL IN COLD WATER OR COLD ALC
Appearance
Solid Powder
Application
Used in cosmetics, pharmaceuticals, food additives, waterproofing agents, plastic stabilizers, emulsifiers, and rubber lubricants and dusting agents; Stearic acid occurs naturally in human and animal fats and oils and in some vegetable oils, including cocoa oil. Stearic acid can be prepared from animal fat (triglyceride) by treating with water at high temperature, leading to hydrolysis of triglycerides, or by hydrogenation of unsaturated vegetable oils such as cottonseed oil.
Storage
2-8°C
Stability
Stable. Incompatible with strong oxidizing agents.
LogP
4.99780
Odor
SLIGHT, TALLOW-LIKE ODOR

Safety Information

Hazards
H319:
Causes serious eye irritation.
H411:
Toxic to aquatic life with long-lasting effects.
Precautionary Statement
P264:
Wash thoroughly after handling.
P273:
Avoid release to the environment.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P391:
Collect spillage.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.

Computed Properties

Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
16
Exact Mass
306.25347464 g/mol
Monoisotopic Mass
306.25347464 g/mol
Topological Polar Surface Area
40.1Ų
Heavy Atom Count
21
Formal Charge
0
Complexity
207
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
2
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
US-11028172-B1 Anti-TIGIT antibodies and uses thereof 2020-11-10
US-11028174-B1 Bifunctional molecules targeting PD-L1 and TGF-β 2020-07-28
US-11020349-B1 Transmucosal dosage forms of remdesivir 2020-07-14
US-10988479-B1 Morphic forms of trilaciclib and methods of manufacture thereof 2020-06-15
US-10973908-B1 Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine 2020-05-14
US-10980756-B1 Methods of treatment 2020-03-16
EP-3842489-A1 Heterophasic propylene polymer material and use of the same 2019-12-24
US-2021189110-A1 Heterophasic propylene polymer material and use of the same 2019-12-24
EP-3842036-A1 Sustained-release injectable composition comprising finasteride 2019-12-23
US-2021186864-A1 Sustained-release injectable composition comprising finasteride 2019-12-23

Literatures

PMID Publication Date Title Journal
32347412 2021-02-01 Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism Cell biology and toxicology
31590850 2020-01-01 Functional chitosan oligosaccharide nanomicelles for topical ocular drug delivery of dexamethasone Carbohydrate polymers
24242247 2014-01-01 Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola Applied and environmental microbiology
23878198 2013-08-30 Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase The Journal of biological chemistry
23030001 2012-12-01 Synthesis of cytarabine lipid drug conjugate for treatment of meningeal leukemia: development, characterization and in vitro cell line studies Journal of biomedical nanotechnology
22652220 2012-11-01 Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan International journal of biological macromolecules
23054739 2012-11-01 Comparison of methods for evaluation of activity of photocatalytic films Environmental science and pollution research international
23037881 2012-10-26 Nano-TiO2/polyurethane composites for antibacterial and self-cleaning coatings Nanotechnology
22728259 2012-10-15 Influence of compaction properties and interfacial topography on the performance of bilayer tablets International journal of pharmaceutics
22956328 2012-10-15 Distinguishing wild ruminant lipids by gas chromatography/combustion/isotope ratio mass spectrometry Rapid communications in mass spectrometry : RCM
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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