Sodium stearate
Product Information
Molecular Formula
C18H35NaO2
Molecular Weight
306.466
Description
Sodium stearate is used as a surfactant to aid the solubility of hydrophobic compounds in the pharmaceutical industry.
Synonyms
Stearic acid, sodium salt
IUPAC Name
sodiumoctadecanoate
SMILES
CCCCCCCCCCCCCCCCCC(=O)[O-].[Na+]
InChI
InChI=1S/C18H36O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2-17H2,1H3,(H,19,20);/q;+1/p-1
InChI Key
RYYKJJJTJZKILX-UHFFFAOYSA-M
Melting Point
220 °C
Flash Point
162.4°C
Purity
>97.0%(T)
Density
1.103 g/cm³
Solubility
SLOWLY SOL IN COLD WATER OR COLD ALC
Appearance
Solid Powder
Application
Used in cosmetics, pharmaceuticals, food additives, waterproofing agents, plastic stabilizers, emulsifiers, and rubber lubricants and dusting agents; Stearic acid occurs naturally in human and animal fats and oils and in some vegetable oils, including cocoa oil. Stearic acid can be prepared from animal fat (triglyceride) by treating with water at high temperature, leading to hydrolysis of triglycerides, or by hydrogenation of unsaturated vegetable oils such as cottonseed oil.
Storage
Keep container tightly closed in a dry and well-ventilated place.
Stability
Stable. Incompatible with strong oxidizing agents.
LogP
4.99780
Odor
SLIGHT, TALLOW-LIKE ODOR
Safety Information
Hazards
H319:
Causes serious eye irritation.
H411:
Toxic to aquatic life with long-lasting effects.
Causes serious eye irritation.
H411:
Toxic to aquatic life with long-lasting effects.
Precautionary Statement
P264:
Wash thoroughly after handling.
P273:
Avoid release to the environment.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P391:
Collect spillage.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Wash thoroughly after handling.
P273:
Avoid release to the environment.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P391:
Collect spillage.
P501:
Dispose of contents/container in accordance with local/regional/national/international regulations.
Computed Properties
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
16
Exact Mass
306.25347464 g/mol
Monoisotopic Mass
306.25347464 g/mol
Topological Polar Surface Area
40.1Ų
Heavy Atom Count
21
Formal Charge
0
Complexity
207
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
2
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-11028172-B1 | Anti-TIGIT antibodies and uses thereof | 2020-11-10 |
| US-11028174-B1 | Bifunctional molecules targeting PD-L1 and TGF-β | 2020-07-28 |
| US-11020349-B1 | Transmucosal dosage forms of remdesivir | 2020-07-14 |
| US-10988479-B1 | Morphic forms of trilaciclib and methods of manufacture thereof | 2020-06-15 |
| US-10973908-B1 | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine | 2020-05-14 |
| US-10980756-B1 | Methods of treatment | 2020-03-16 |
| EP-3842489-A1 | Heterophasic propylene polymer material and use of the same | 2019-12-24 |
| US-2021189110-A1 | Heterophasic propylene polymer material and use of the same | 2019-12-24 |
| EP-3842036-A1 | Sustained-release injectable composition comprising finasteride | 2019-12-23 |
| US-2021186864-A1 | Sustained-release injectable composition comprising finasteride | 2019-12-23 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 32347412 | 2021-02-01 | Roles of acyl-CoA synthetase long-chain family member 5 and colony stimulating factor 2 in inhibition of palmitic or stearic acids in lung cancer cell proliferation and metabolism | Cell biology and toxicology |
| 31590850 | 2020-01-01 | Functional chitosan oligosaccharide nanomicelles for topical ocular drug delivery of dexamethasone | Carbohydrate polymers |
| 24242247 | 2014-01-01 | Expression and characterization of CYP52 genes involved in the biosynthesis of sophorolipid and alkane metabolism from Starmerella bombicola | Applied and environmental microbiology |
| 23878198 | 2013-08-30 | Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase | The Journal of biological chemistry |
| 23030001 | 2012-12-01 | Synthesis of cytarabine lipid drug conjugate for treatment of meningeal leukemia: development, characterization and in vitro cell line studies | Journal of biomedical nanotechnology |
| 22652220 | 2012-11-01 | Anticancer effect of atorvastatin nanostructured polymeric micelles based on stearyl-grafted chitosan | International journal of biological macromolecules |
| 23054739 | 2012-11-01 | Comparison of methods for evaluation of activity of photocatalytic films | Environmental science and pollution research international |
| 23037881 | 2012-10-26 | Nano-TiO2/polyurethane composites for antibacterial and self-cleaning coatings | Nanotechnology |
| 22728259 | 2012-10-15 | Influence of compaction properties and interfacial topography on the performance of bilayer tablets | International journal of pharmaceutics |
| 22956328 | 2012-10-15 | Distinguishing wild ruminant lipids by gas chromatography/combustion/isotope ratio mass spectrometry | Rapid communications in mass spectrometry : RCM |
