Terephthalamidine
Product Information
Molecular Formula
C8H10N4
Molecular Weight
162.20
Description
Terephthalamidine, a phthalanilide derivative, could bind to DNA double helix selectively.
Synonyms
Terephthalamidine; 1,4-Diamidinobenzene; 1,4-Benzenedicarboximidamide; Benzene-1,4-dicarboximidamide
IUPAC Name
benzene-1,4-dicarboximidamide
SMILES
C1=CC(=CC=C1C(=N)N)C(=N)N
InChI
InChI=1S/C8H10N4/c9-7(10)5-1-2-6(4-3-5)8(11)12/h1-4H,(H3,9,10)(H3,11,12)
InChI Key
UNMMLGAPDZGRJJ-UHFFFAOYSA-N
Purity
98%
Appearance
Powder
Storage
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
Computed Properties
XLogP3
-0.8
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
2
Exact Mass
162.090546336
Monoisotopic Mass
162.090546336
Topological Polar Surface Area
99.7
Heavy Atom Count
12
Formal Charge
0
Complexity
169
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2021015336-A1 | SINGLE DOMAIN ANTIBODY TARGETING αVβ3 INTEGRIN | 2019-07-24 |
| EP-3916014-A1 | SINGLE DOMAIN ANTIBODY TARGETING aVß3 INTEGRIN | 2019-07-24 |
| US-2022133913-A1 | SINGLE DOMAIN ANTIBODY TARGETING aVB3 INTEGRIN | 2019-07-24 |
| WO-2020242217-A1 | Liposome comprising glutathione-s-transferase and protein having capacity to bind to target cell or target protein, and use thereof | 2019-05-28 |
| WO-2020218791-A1 | BISPECIFIC ANTIBODY SPECIFICALLY BINDING TO IL-17A AND TNF-α | 2019-04-26 |
| US-2022098297-A1 | BISPECIFIC ANTIBODY SPECIFICALLY BINDING TO IL-17A AND TNF-Alpha | 2019-04-26 |
| EP-3718540-A1 | Fusion protein comprising glutathione-s-transferase and protein having binding affinity target cell or target protein, and use thereof | 2017-11-28 |
| US-2021000971-A1 | Fusion protein comprising glutathione-s-transferase and protein having binding affinity target cell or target protein, and use thereof | 2017-11-28 |
| WO-2019040750-A1 | MULTIVALENT LIGAND FOR MYOTONIC DYSTROPHY | 2017-08-25 |
| WO-2019040750-A9 | A multivalent ligand for myotonic dystrophy | 2017-08-25 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22346912 | 2012-02-01 | 4-Meth-oxy-benzamidinium 2,6-dimeth-oxy-benzoate | Acta crystallographica. Section E, Structure reports online |
| 21599440 | 2011-01-01 | Multidentate terephthalamidate and hydroxypyridonate ligands: towards new orally active chelators | Hemoglobin |
| 19899775 | 2009-12-04 | Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins | The Journal of organic chemistry |
| 19164981 | 2009-01-01 | Soccer-related facial fractures: postoperative management with facial protective shields | The Journal of craniofacial surgery |
| 16634594 | 2006-05-01 | Synthesis and thermodynamic evaluation of mixed hexadentate linear iron chelators containing hydroxypyridinone and terephthalamide units | Inorganic chemistry |
| 15826183 | 2005-04-20 | Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction | Journal of the American Chemical Society |
| 15606751 | 2004-12-01 | Kinetic analysis of zymogen autoactivation in the presence of a reversible inhibitor | European journal of biochemistry |
| 15006365 | 2004-03-22 | Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein | Bioorganic & medicinal chemistry letters |
| 11983988 | 2002-05-01 | N,N',N',N''-Tetraethylterephthalamidinium bis(tetrazolate) | Acta crystallographica. Section C, Crystal structure communications |
| 11706273 | 2001-11-01 | Benzdiamidine | Acta crystallographica. Section C, Crystal structure communications |
