Terephthalamidine

Product Information

Molecular Formula:
C8H10N4
Molecular Weight:
162.20
Description
Terephthalamidine, a phthalanilide derivative, could bind to DNA double helix selectively.
Synonyms
Terephthalamidine; 1,4-Diamidinobenzene; 1,4-Benzenedicarboximidamide; Benzene-1,4-dicarboximidamide
IUPAC Name
benzene-1,4-dicarboximidamide
Canonical SMILES
C1=CC(=CC=C1C(=N)N)C(=N)N
InChI
InChI=1S/C8H10N4/c9-7(10)5-1-2-6(4-3-5)8(11)12/h1-4H,(H3,9,10)(H3,11,12)
InChI Key
UNMMLGAPDZGRJJ-UHFFFAOYSA-N
Purity
98%
Appearance
Powder
Storage
Store in a cool and dry place and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).

Computed Properties

XLogP3
-0.8
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
2
Exact Mass
162.090546336
Monoisotopic Mass
162.090546336
Topological Polar Surface Area
99.7
Heavy Atom Count
12
Formal Charge
0
Complexity
169
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
WO-2021015336-A1 SINGLE DOMAIN ANTIBODY TARGETING αVβ3 INTEGRIN 2019-07-24
EP-3916014-A1 SINGLE DOMAIN ANTIBODY TARGETING aVß3 INTEGRIN 2019-07-24
US-2022133913-A1 SINGLE DOMAIN ANTIBODY TARGETING aVB3 INTEGRIN 2019-07-24
WO-2020242217-A1 Liposome comprising glutathione-s-transferase and protein having capacity to bind to target cell or target protein, and use thereof 2019-05-28
WO-2020218791-A1 BISPECIFIC ANTIBODY SPECIFICALLY BINDING TO IL-17A AND TNF-α 2019-04-26
US-2022098297-A1 BISPECIFIC ANTIBODY SPECIFICALLY BINDING TO IL-17A AND TNF-Alpha 2019-04-26
EP-3718540-A1 Fusion protein comprising glutathione-s-transferase and protein having binding affinity target cell or target protein, and use thereof 2017-11-28
US-2021000971-A1 Fusion protein comprising glutathione-s-transferase and protein having binding affinity target cell or target protein, and use thereof 2017-11-28
WO-2019040750-A1 MULTIVALENT LIGAND FOR MYOTONIC DYSTROPHY 2017-08-25
WO-2019040750-A9 A multivalent ligand for myotonic dystrophy 2017-08-25

Literatures

PMID Publication Date Title Journal
22346912 2012-02-01 4-Meth-oxy-benzamidinium 2,6-dimeth-oxy-benzoate Acta crystallographica. Section E, Structure reports online
21599440 2011-01-01 Multidentate terephthalamidate and hydroxypyridonate ligands: towards new orally active chelators Hemoglobin
19899775 2009-12-04 Synthesis of bivalent lactosides based on terephthalamide, N,N'-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins The Journal of organic chemistry
19164981 2009-01-01 Soccer-related facial fractures: postoperative management with facial protective shields The Journal of craniofacial surgery
16634594 2006-05-01 Synthesis and thermodynamic evaluation of mixed hexadentate linear iron chelators containing hydroxypyridinone and terephthalamide units Inorganic chemistry
15826183 2005-04-20 Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction Journal of the American Chemical Society
15606751 2004-12-01 Kinetic analysis of zymogen autoactivation in the presence of a reversible inhibitor European journal of biochemistry
15006365 2004-03-22 Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein Bioorganic & medicinal chemistry letters
11983988 2002-05-01 N,N',N',N''-Tetraethylterephthalamidinium bis(tetrazolate) Acta crystallographica. Section C, Crystal structure communications
11706273 2001-11-01 Benzdiamidine Acta crystallographica. Section C, Crystal structure communications
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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