Trimethyltin chloride

Product Information

Molecular Formula:
C3H9ClSn
Molecular Weight:
199.27
Description
Trimethyltin chloride is an organotin reagent widely used in transferring trimethylstannyl groups onto the substrates to synthesize various organostannanes. Trimethylstannyl compounds derived from this reagent, are extensively used in the palladium-catalyzed Stille coupling reactions.
Synonyms
CHLOROTRIMETHYLSTANNANE; CHLOROTRIMETHYLTIN; TIN TRIMETHYL CHLORIDE; TRIMETHYLCHLOROTIN; TRIMETHYLTIN(IV) CHLORIDE; TRIMETHYLTIN CHLORIDE; (CH3)3SnCl; ai3-28454
IUPAC Name
chloro(trimethyl)stannane
Canonical SMILES
C[Sn](C)(C)Cl
InChI
InChI=1S/3CH3.ClH.Sn/h3*1H31H/q+1/p-1
InChI Key
KWTSZCJMWHGPOS-UHFFFAOYSA-M
Boiling Point
148°C
Melting Point
37-39°C
Flash Point
206.6 °F - closed cup
Purity
>98.0%(GC)
Density
0.988 g/mL at 25 °C
Solubility
Soluble in chloroform and organic solvents.
Appearance
Solid.
Application
A byproduct of methyltin manufacture; Used as an experimental pesticide.
Storage
Poison room
Decomposition
When heated to decomposition it emits toxic fumes of chlorides.

Safety Information

Hazards
H300 + H310 + H330 - H410
Precautionary Statement
P262 - P273 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310

Computed Properties

Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
0
Rotatable Bond Count
0
Exact Mass
199.941481 g/mol
Monoisotopic Mass
199.941481 g/mol
Topological Polar Surface Area
0Ų
Heavy Atom Count
5
Formal Charge
0
Complexity
28.4
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
CN-113929880-A Ester thiazole wide band gap polymer and application thereof in photoelectric device 2021-10-29
CN-113717216-A Preparation method of trimethyltin chloride 2021-10-15
CN-113956446-A Semiconductor polymer for treating hypoxic tumor, preparation method and application 2021-10-12
CN-113880829-A Organic photovoltaic material with central structural unit having non-condensed characteristic and preparation method thereof 2021-09-29
CN-113831514-A End-capped polymer and preparation method and application thereof 2021-09-28
CN-113788854-A Preparation method of isooctyl thioglycolate trimethyl tin 2021-09-24
CN-113861389-A Polymer semiconductors containing quinoid donor-acceptor units, their preparation and use 2021-09-15
CN-113501940-A D-A type conjugated polymer and preparation method and application thereof 2021-08-26
CN-113698422-A Organic small molecule receptor material based on asymmetric thieno-isobenzopyran units and application 2021-08-24
CN-113861388-A Melt-processable polymer material, and preparation method and application thereof 2021-08-18

Literatures

PMID Publication Date Title Journal
33865920 2021-07-01 The main mechanisms of trimethyltin chloride-induced neurotoxicity: Energy metabolism disorder and peroxidation damage Toxicology letters
32879254 2020-01-01 Mechanism in bradycardia induced by Trimethyltin chloride: Inhibition activity and expression of Na+/K+-ATPase and apoptosis in myocardia The Journal of toxicological sciences
30993381 2019-06-01 In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice Archives of toxicology
27729293 2017-02-01 Development and characterization of a human embryonic stem cell-derived 3D neural tissue model for neurotoxicity testing Toxicology in vitro : an international journal published in association with BIBRA
27015953 2017-01-01 Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay Archives of toxicology
23423712 2013-07-01 Apoptosis induced by trimethyltin chloride in human neuroblastoma cells SY5Y is regulated by a balance and cross-talk between NF-κB and MAPKs signaling pathways Archives of toxicology
23000284 2012-12-16 Early life stage trimethyltin exposure induces ADP-ribosylation factor expression and perturbs the vascular system in zebrafish Toxicology
22426162 2012-05-15 The selective norepinephrine reuptake inhibitor atomoxetine counteracts behavioral impairments in trimethyltin-intoxicated rats European journal of pharmacology
22357484 2011-10-01 [The protein expression profiles induced by trimethyltin chloride in Vero cells] Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
22130242 2011-01-01 Indomethacin ameliorates trimethyltin-induced neuronal damage in vivo by attenuating oxidative stress in the dentate gyrus of mice Biological & pharmaceutical bulletin
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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