TRIS(HYDROXYMETHYL)PHOSPHINE
Product Information
Molecular Formula
C3H9O3P
Molecular Weight
124.08
Description
TRIS(HYDROXYMETHYL)PHOSPHINE is a pivotal chemical entity applied in the biomedical sector. It possesses distinctive characteristics rendering it a potent reducing agent in diverse pharmaceutical drug syntheses. Furthermore, TRIS(HYDROXYMETHYL)PHOSPHINE assumes a paramount role in tackling specific ailments, including oxidative stress-linked disorders and neurodegenerative conditions.
Synonyms
PHOSPHINIDYNETRIMETHANOL; TRIS(HYDROXYMETHYL)PHOSPHINE; phosphinidynetri-methano; phosphinidynetris-methano; phosphinidynetrismethanol; trimethylolphosphine
IUPAC Name
bis(hydroxymethyl)phosphanylmethanol
SMILES
C(O)P(CO)CO
InChI
InChI=1S/C3H9O3P/c4-1-7(2-5)3-6/h4-6H,1-3H2
InChI Key
JMXMXKRNIYCNRV-UHFFFAOYSA-N
Boiling Point
111-113°C2.5 mm Hg(lit.)
Melting Point
48-56°C(lit.)
Flash Point
Not applicable
Purity
95%
Appearance
White powder or cryalline solids
Safety Information
Hazards
H301 - H315 - H318 - H335
Precautionary Statement
P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
Computed Properties
XLogP3
-1.8
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
3
Exact Mass
124.02893114 g/mol
Monoisotopic Mass
124.02893114 g/mol
Topological Polar Surface Area
60.7Ų
Heavy Atom Count
7
Formal Charge
0
Complexity
31.7
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-113249371-A | Preparation method and application of immobilized cells for tagatose production | 2021-07-05 |
| CN-113249371-B | Preparation method and application of immobilized cells for tagatose production | 2021-07-05 |
| US-11220707-B1 | Compositions and methods for pairwise sequencing | 2021-06-17 |
| US-11236388-B1 | Compositions and methods for pairwise sequencing | 2021-06-17 |
| JP-2021050344-A | Fabric care composition containing glyceride copolymer | 2020-12-01 |
| CN-113956425-A | Reactive flame-retardant polyurethane foam containing phosphate ester structure and preparation method thereof | 2020-09-17 |
| WO-2022053769-A2 | Fluorescent reporter and use thereof for the detection of target molecules | 2020-09-11 |
| EP-3964515-A1 | High affinity macrocyclic fkb51-inhibitors for treatment of psychiatric disorders | 2020-09-04 |
| WO-2022049005-A1 | High affinity macrocyclic fkb51-inhibitors for treatment of psychiatric disorders | 2020-09-04 |
| WO-2022003040-A1 | Process for treating keratin fibers using particular amino acids in high concentration | 2020-06-30 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 21504026 | 2011-05-01 | Assembly of collagen fibril meshes using gold nanoparticles functionalized with tris(hydroxymethyl)phosphine-alanine as multivalent cross-linking agents | Journal of molecular recognition : JMR |
| 21194623 | 2011-02-01 | In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands | Journal of inorganic biochemistry |
| 21234407 | 2010-12-27 | Potential Applications of Immobilized β-Galactosidase in Food Processing Industries | Enzyme research |
| 19164659 | 2009-02-01 | Immobilization of recombinant thermostable beta-galactosidase from Bacillus stearothermophilus for lactose hydrolysis in milk | Journal of dairy science |
| 21201983 | 2008-03-05 | Chloridotris[tris-(4-fluoro-phen-yl)phosphine]rhodium(I) methanol solvate | Acta crystallographica. Section E, Structure reports online |
| 18251492 | 2008-02-27 | In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand | Journal of medicinal chemistry |
| 21201856 | 2008-02-08 | trans-Carbonyl-chloridobis(tri-p-tolyl-phosphine)rhodium(I) acetone solvate | Acta crystallographica. Section E, Structure reports online |
| 18043951 | 2008-02-01 | Synthesis, in vitro and in vivo characterization of (64)Cu(I) complexes derived from hydrophilic tris(hydroxymethyl)phosphane and 1,3,5-triaza-7-phosphaadamantane ligands | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry |
| 21200527 | 2007-12-12 | trans-Carbonyl-chloridobis(ethyl-diphenyl-phosphine-κP)rhodium(I) | Acta crystallographica. Section E, Structure reports online |
| 17149861 | 2006-12-14 | Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand | Journal of medicinal chemistry |
