Brij52
Product Information
Molecular Formula
C16H33(C2H4O)nOH
Molecular Weight
1123.5
Description
It is a non-ionic surfactant, mainly used as an emulsifier for water-in-oil and oil-in-water emulsions, as well as a stabilizer for microemulsions and multiple emulsions. It can be used as a solubilizing agent for essential oils, perfumery chemicals, vitamin oils and low water-soluble drugs, as an antidusting agent for powders, as a wetting and dispersing agent for coarse-grained liquids, and as a detergent, especially for shampoos, face cleansers and similar cosmetic cleaners, as well as a gelling and foaming agent.
Synonyms
Polyethylene glycol monocetyl ether; Polyethylene Glycol Monohexadecyl Ether; Polyoxyethylene Monocetyl Ether; Alfonic 16-8; Anapoe 58; Brij 52; Brij 58P; Ceteth 10; Cetyl alcohol ethoxylate; Hexadecanol poly(oxyethylene) ether; Hexadecylpoly(ethyleneoxy)ethanol; Oxyethylenated hexadecyl alcohol; PEG monocetyl ether; POE cetyl ether; Poly(oxyethylene) cetyl ether; Poly(oxyethylene) hexadecylether; Poly(oxyethylene) palmityl ether
IUPAC Name
2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
SMILES
CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI
InChI=1S/C56H114O21/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-58-19-21-60-23-25-62-27-29-64-31-33-66-35-37-68-39-41-70-43-45-72-47-49-74-51-53-76-55-56-77-54-52-75-50-48-73-46-44-71-42-40-69-38-36-67-34-32-65-30-28-63-26-24-61-22-20-59-18-16-57/h57H,2-56H2,1H3
InChI Key
NLMKTBGFQGKQEV-UHFFFAOYSA-N
Melting Point
41-49°C
Flash Point
> 230°C
Purity
95%
Density
0.978 g/mL at 25°C(lit.)
Solubility
Soluble in Water
Appearance
off-white waxy solid
Application
Non-ionic surfactant used as a solubilizer and emulsifying agent in foods, cosmetics, and pharmaceuticals; Also used as a research tool.
Storage
Store at RT
Refractive Index
n20/D 1.466(lit.)
Stability
Stable. Combustible. Incompatible with strong oxidizing agents.
Computed Properties
XLogP3
4.5
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
21
Rotatable Bond Count
74
Exact Mass
1122.78526064 g/mol
Monoisotopic Mass
1122.78526064 g/mol
Topological Polar Surface Area
205Ų
Heavy Atom Count
77
Formal Charge
0
Complexity
999
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022046634-A1 | Vaccines against sars-cov-2 infections | 2020-08-24 |
| WO-2022040453-A1 | Blood cell lysing agent for isolating bacteria from blood culture | 2020-08-20 |
| WO-2022038144-A1 | Novel nanopore-forming polypeptides | 2020-08-18 |
| US-2022018785-A1 | Compositions and methods for assay measurements | 2020-07-01 |
| WO-2022006236-A1 | Compositions and methods for assay measurements | 2020-07-01 |
| US-2021401710-A1 | Azoxystrobin efficacy in personal care forms | 2020-06-26 |
| WO-2021262229-A1 | Azoxystrobin efficacy in personal care formulations | 2020-06-26 |
| WO-2021249760-A1 | A cosmetic composition comprising 6-methyl-picolinamide | 2020-06-10 |
| WO-2021247542-A2 | Pharmaceutical compositions comprising insoluble active ingredients | 2020-06-01 |
| WO-2021242908-A1 | Method of determining surfactant concentration in a protein sample | 2020-05-26 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22851616 | 2012-11-01 | ATP serves as an endogenous inhibitor of UDP-glucuronosyltransferase (UGT): a new insight into the latency of UGT | Drug metabolism and disposition: the biological fate of chemicals |
| 22659127 | 2012-09-15 | Idebenone-loaded solid lipid nanoparticles for drug delivery to the skin: in vitro evaluation | International journal of pharmaceutics |
| 21387348 | 2012-07-01 | Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats | Journal of applied toxicology : JAT |
| 22360489 | 2012-06-19 | Stability of gold nanorods passivated with amphiphilic ligands | Langmuir : the ACS journal of surfaces and colloids |
| 22265911 | 2012-04-15 | Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging | International journal of pharmaceutics |
| 22035695 | 2011-12-02 | Development of a fritless packed column for capillary electrochromatography-mass spectrometry | Journal of chromatography. A |
| 21720655 | 2011-07-01 | A bilateral comparison study of pimecrolimus cream 1% and a topical medical device cream in the treatment of patients with atopic dermatitis | Journal of drugs in dermatology : JDD |
| 21204752 | 2011-06-01 | In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain | Drug development and industrial pharmacy |
| 21315822 | 2011-06-01 | Expression and purification of full-length anti-apoptotic Bcl-2 using cell-free protein synthesis | Protein expression and purification |
| 21075184 | 2011-02-14 | Magnetic microparticles based on natural polymers | International journal of pharmaceutics |
