Cetalkonium chloride

C25H46ClN

396.09

Cetalkonium chloride is a quaternary ammonium compound and cationic surfactant used as an antiseptic, preservative, and antimicrobial agent. It interacts with negative charges on bacterial cell membranes, disrupting membrane integrity and causing cell death. The compound exhibits broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria including MRSA, E. coli, A. baumannii, K. pneumoniae, and E. faecium, with MICs ranging from 1.0 μg/mL to 126.0 μM. It also shows antibiofilm properties and antiviral activity against Lassa, Marburg, and Ebola viruses. Cetalkonium chloride is FDA-approved for use in over-the-counter topical products as a skin protectant, and is found in formulations for mouth, throat, and eye infections (e.g., Bonjela mouth ulcer gel). It also serves as an excipient in ocular drug delivery systems, improving precorneal residence time and bioavailability.

Benzenemethanaminium, N-hexadecyl-N,N-dimethyl-, chloride (1:1); Benzylhexadecyldimethylammonium chloride; Ammonyx G; Benzylcetyldimethylammonium chloride; Cetol; Cetyldimethylbenzylammonium chloride; Cetylon; Cetyl zephiran; Dimethylbenzylhexadecylammonium chloride; N-Hexadecyl-N-benzyl-N,N-dimethylammonium chloride; Hexadecyldimethylbenzylammonium chloride; n-Hexadecyldimethylbenzylammonium chloride; Pharycidin Concentrate; Tetraseptan; Zettyn chloride; Hexadecylbenzyldimethylammonium chloride; Dimethylbenzylcetylammonium chloride; Acinol; Ammonyx T; Cetylbenzyldimethylammonium chloride; Benzyldimethylhexadecylammonium chloride; DMCBAC; Dehyquart CBB; N-Benzyl-N-cetyldimethylammonium chloride; Baktonium; Win 357; Banicol; Benzaletas; Bicetonium; Bonjela; Spilan; Dehyquart CDB; CDBAC; Benzyldimethylcetylammonium chloride; Querton 16BCL; Sanisol C; Acquat CDAC; Acetoquate CDAC; Zettyn; N-Hexadecyl-N,N-dimethyl-N-benzylammonium chloride; Benzyl-n-hexadecyldimethylammonium chloride; HBAC; N-Benzyl-N,N-dimethyl-N-hexadecylammonium chloride; (Hexadecyl)(dimethyl)(benzyl)amonium chloride

benzyl-hexadecyl-dimethylazanium;chloride

CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1.[Cl-]

InChI=1S/C25H46N.ClH/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23-26(2,3)24-25-21-18-17-19-22-25/h17-19,21-22H,4-16,20,23-24H2,1-3H31H/q+1/p-1

SXPWTBGAZSPLHA-UHFFFAOYSA-M

54-56 °C

>97.0% by HPLC

Soluble in DMSO

White to milky white powder

A quaternary surfactant used as a germicide/fungicide in leather processing, textile dyeing, and silicone-based water repellents.

Store at RT

10328-34-4 (free base)

H315:
Causes skin irritation.
H319:
Causes serious eye irritation.

P264:
Wash thoroughly after handling.
P280:
Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:
IF ON SKIN:
Wash with plenty of soap and water.
P332+P313:
If skin irritation occurs:
Get medical advice/attention.
P337+P313:
If eye irritation persists:
Get medical advice/attention.
P362+P364:
Take off contaminated clothing. [As modified by IV ATP].
And wash it before reuse. [Added by IV ATP].