Cyclen
Product Information
Molecular Formula
C8H24N4
Molecular Weight
172.27
Description
Cyclen is an impurity of Gadobutrol. It is a contrast agent administered intravenously during MRI and MRA procedures to improve visualization of specific tissues and blood vessels.
Synonyms
1,4,7,10-Tetraazacyclododecane; cyclen (1,4,7,10-tetraazacyclododecane)
IUPAC Name
1,4,7,10-tetrazacyclododecane
SMILES
C1CNCCNCCNCCN1
InChI
InChI=1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2
InChI Key
QBPPRVHXOZRESW-UHFFFAOYSA-N
Boiling Point
283.8±8.0 °C at 760 mmHg
Melting Point
110-113 °C (lit.)
Flash Point
Not applicable
Purity
>98%
Density
0.9±0.1 g/cm3
Appearance
Powder
Safety Information
Hazards
H302 - H312 - H314 - H410
Precautionary Statement
P273 - P280 - P305 + P351 + P338 - P310 - P501
Computed Properties
XLogP3
-2.4
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
4
Rotatable Bond Count
0
Exact Mass
172.16879665 g/mol
Monoisotopic Mass
172.16879665 g/mol
Topological Polar Surface Area
48.1Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
65.1
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114116537-A | Method and device for adaptively fusing address and instruction cache | 2021-11-25 |
| CN-114169154-A | Expansive force prediction method, expansive force prediction system, electronic device, and storage medium | 2021-11-25 |
| CN-113929102-A | Method for preparing high-purity silicic acid by using chelation principle | 2021-11-24 |
| CN-113999185-A | Preparation method of high-purity Magnetic Resonance Imaging (MRI) drug intermediate | 2021-11-18 |
| CN-114028590-A | Granzyme B targeting complex, radiopharmaceutical, preparation methods and applications thereof | 2021-11-18 |
| CN-114014843-A | PSMA (patterned beam-selective membrane antigen) targeted nuclide/fluorescent bimodal ligand, molecular probe and application | 2021-11-17 |
| CN-114071781-A | Wireless local area network medium access control method | 2021-11-16 |
| CN-114163499-A | Cadherin inhibitor and preparation method and application thereof | 2021-11-11 |
| CN-114034629-A | Rock mass dry-wet circulation damage monitoring system and method in chemical corrosion environment | 2021-11-10 |
| CN-114170472-A | Image processing method, readable storage medium and computer terminal | 2021-10-19 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 23613345 | 2013-06-10 | A cyclen-based tetraphosphinate chelator for the preparation of radiolabeled tetrameric bioconjugates | Chemistry (Weinheim an der Bergstrasse, Germany) |
| 22996043 | 2012-11-18 | A chirality rewriting cycle mediated by a dynamic cyclen-calcium complex | Chemical communications (Cambridge, England) |
| 22974321 | 2012-10-01 | New trick for an old ligand! The sensing of Zn(II) using a lanthanide based ternary Yb(III)-cyclen-8-hydroxyquinoline system as a dual emissive probe for displacement assay | Inorganic chemistry |
| 22825538 | 2012-09-07 | Intracomplex general acid/base catalyzed cleavage of RNA phosphodiester bonds: the leaving group effect | Organic & biomolecular chemistry |
| 22928524 | 2012-09-07 | Argentivorous molecules: structural evidence for Ag(+)-π interactions in solution | Organic letters |
| 22821878 | 2012-09-01 | DOTAM-type ligands possessing arginine pendant groups for use in PARACEST MRI | Contrast media & molecular imaging |
| 22658660 | 2012-07-06 | Cation separation and preconcentration using columns containing cyclen and cyclen-resorcinarene derivatives | Journal of chromatography. A |
| 22651379 | 2012-06-18 | Monopicolinate cyclen and cyclam derivatives for stable copper(II) complexation | Inorganic chemistry |
| 22321835 | 2012-06-01 | Cationic lipids containing cyclen and ammonium moieties as gene delivery vectors | Chemical biology & drug design |
| 22507054 | 2012-05-07 | Structural basis for bifunctional zinc(II) macrocyclic complex recognition of thymine bulges in DNA | Inorganic chemistry |
