GI 530159
Product Information
Molecular Formula
C27H20F6N2O2
Molecular Weight
518.45
Description
GI 530159 is a TREK1 and TREK2 channel activator exhibiting selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels.
Synonyms
4,4'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis[benzenamine]; 4,4'-(Hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline
IUPAC Name
4-[4-[2-[4-(4-aminophenoxy)phenyl]-1,1,1,3,3,3-hexafluoropropan-2-yl]phenoxy]aniline
SMILES
C1=CC(=CC=C1C(C2=CC=C(C=C2)OC3=CC=C(C=C3)N)(C(F)(F)F)C(F)(F)F)OC4=CC=C(C=C4)N
InChI
InChI=1S/C27H20F6N2O2/c28-26(29,30)25(27(31,32)33,17-1-9-21(10-2-17)36-23-13-5-19(34)6-14-23)18-3-11-22(12-4-18)37-24-15-7-20(35)8-16-24/h1-16H,34-35H2
InChI Key
HHLMWQDRYZAENA-UHFFFAOYSA-N
Boiling Point
544.8±50.0 °C (Predicted)
Melting Point
159-163 °C (lit.)
Purity
≥ 99 % by HPLC
Density
1.3455 (estimate) g/cm3
Solubility
DMSO : 51.84 mg/mL; Ehanol : 25.92 mg/mL
Appearance
Solid powder
LogP
9.00870
Safety Information
Hazards
H302:
Harmful if swallowed.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Harmful if swallowed.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word
Warning
Computed Properties
XLogP3
7.6
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
10
Rotatable Bond Count
6
Exact Mass
518.14289686 g/mol
Monoisotopic Mass
518.14289686 g/mol
Topological Polar Surface Area
70.5Ų
Heavy Atom Count
37
Formal Charge
0
Complexity
641
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114181393-A | Semi-alicyclic polyimide material, semi-alicyclic polyimide film, and preparation method and application thereof | 2022-01-27 |
| CN-114133821-A | Antibacterial lining aluminum plate applied to household appliances and preparation method thereof | 2021-12-31 |
| JP-2022043096-A | Resin composition, method for manufacturing cured relief pattern, and semiconductor device | 2021-12-01 |
| CN-113968987-A | Polyimide-based high-temperature-resistant electromagnetic shielding film and preparation method thereof | 2021-11-30 |
| CN-113969058-A | Antistatic polyimide film and preparation method thereof | 2021-11-30 |
| CN-114015043-A | Method for preparing polyimide powder by chemical method | 2021-11-23 |
| CN-114085398-A | Low-dielectric polyimide film and preparation method thereof | 2021-11-17 |
| CN-114085378-A | Polyamide acid solution and preparation method thereof, polyimide film and preparation method and application thereof | 2021-11-16 |
| CN-113929479-A | Carbon-silicon composite material for new energy automobile brake disc and preparation method thereof | 2021-10-22 |
| CN-113861418-A | Polyimide compound, liquid crystal aligning agent, and preparation method and application thereof | 2021-10-20 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 29150838 | 2018-06-01 | GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability | British journal of pharmacology |
| 22072913 | 2011-01-01 | Comparative kinetic study and microwaves non-thermal effects on the formation of poly(amic acid) 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and 4,4'-(hexafluoroisopropylidene)bis(p-phenyleneoxy)dianiline (BAPHF). Reaction activated by microwave, ultrasound and conventional heating | International journal of molecular sciences |
