Polyoxyethylene stearate
Product Information
Molecular Formula
HO(CH2CH2O)nOCC17H35
Description
Polyoxyethylene stearate is commonly used as an emulsifier and a surfactant in pharmaceutical formulations.
Synonyms
2-Hydroxyethyl stearate; Ethylene glycol monostearate; Glycol stearate; 2-Hydroxyethyl octadecanoate; Cremophor A; Glycol monostearate; Monthybase; Parastarin; Monthyle; Sedetol; Ivorit; Prodhybase ethyl; Prodhybas N; Cerasynt M; Clearate G; Cerasynt MN; Cithrol PS; Clindrol SEG; OCTADECANOIC ACID, 2-HYDROXYETHYL ESTER; Lipo EGMS; Cithrol 10MS; Lactine; Cerasynt 660; Myrj; Tego-stearate; Akyporox S 100; Prodhybase P; PEG stearate; Emerest 2350; Emerest 2640; Empilan 2848; Lamacit CA; Soromin-SG
Boiling Point
438.00 to 439.00 °C at 760.00 mm Hg (est)
Melting Point
47°C
Flash Point
39°C
Density
0.913 g/cm³
Appearance
White solid
Application
Used as a surfactant, emulsifier (cosmetics, pharmaceuticals, textile finishes, defoamers, and baked goods), dye assistant, lubricant, and antistatic agent; Also used in dentifrice compositions and to make creams, lotions, ointments, and pharmaceutical preparations.
Storage
Keep tightly closed in a cool place in a tightly closed container.
Stability
Stable.
LogP
7.629 (est)
Odor
FAINT FATTY ODOR
Safety Information
Handling
Dust mask type N95 (US), Eyeshields, Gloves
| Molecular Weight | Description |
|---|---|
| n=approx. 55 | White to Almost white powder to crystal. Tm is 53℃ |
| n=approx. 10 | White to Almost white powder to lump |
| n=approx. 45 | White to Almost white powder to crystal. Tm is 52℃ |
| n=approx. 4 | White to Almost white powder to lump |
| n=approx. 2 | White to Almost white wax |
| n=approx. 25 | White to Almost white powder to lump. Tm is 39℃ |
| n=approx. 40 | White to Almost white wax. Tm is 47℃. |
Computed Properties
XLogP3
7.8
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
19
Exact Mass
328.29774513 g/mol
Monoisotopic Mass
328.29774513 g/mol
Topological Polar Surface Area
46.5Ų
Heavy Atom Count
23
Formal Charge
0
Complexity
241
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| EP-3818972-A2 | Piroctone olamine granules for use in cosmetic compositions | 2021-01-29 |
| US-11033516-B1 | Combination therapies with disulfiram | 2020-09-18 |
| WO-2021073174-A1 | Multi-walled carbon nanotube composite form-stable phase change material, and preparation method and use therefor | 2020-05-29 |
| WO-2021036533-A1 | Epoxy resin composite form-stable phase change material, preparation method therefor, and application | 2020-04-10 |
| US-11007134-B1 | Ceramide containing capsules, ceramide compositions, and cosmetic compositions thereof | 2020-03-31 |
| US-10980756-B1 | Methods of treatment | 2020-03-16 |
| EP-3677244-A2 | Compositions comprising multilamellar vesicles | 2020-02-04 |
| US-2021186858-A1 | Low irritation skincare cosmetic composition | 2019-12-24 |
| US-2021186848-A1 | Water resistance sunscreen compositions | 2019-12-20 |
| US-2021189292-A1 | Surfactants for cleaning products | 2019-12-20 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22209995 | 2012-02-27 | Controlling lipolysis through steric surfactants: new insights on the controlled degradation of submicron emulsions after oral and intravenous administration | International journal of pharmaceutics |
| 21939700 | 2012-02-10 | Thermally-triggered 'off-on-off' response of gadolinium-hydrogel-lipid hybrid nanoparticles defines a customizable temperature window for non-invasive magnetic resonance imaging thermometry | Journal of controlled release : official journal of the Controlled Release Society |
| 22119655 | 2012-01-23 | Octreotide-modified and pH-triggering polymeric micelles loaded with doxorubicin for tumor targeting delivery | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences |
| 21770405 | 2011-10-03 | Effect of octreotide-polyethylene glycol(100) monostearate modification on the pharmacokinetics and cellular uptake of nanostructured lipid carrier loaded with hydroxycamptothecine | Molecular pharmaceutics |
| 21558002 | 2011-09-01 | Lipid nanocapsules for dermal application: a comparative study of lipid-based versus polymer-based nanocarriers | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V |
| 20740670 | 2011-02-01 | Oral apomorphine delivery from solid lipid nanoparticles with different monostearate emulsifiers: pharmacokinetic and behavioral evaluations | Journal of pharmaceutical sciences |
| 20934499 | 2010-12-15 | Thiolated nanostructured lipid carriers as a potential ocular drug delivery system for cyclosporine A: Improving in vivo ocular distribution | International journal of pharmaceutics |
| 20149853 | 2010-05-10 | In vitro drug release mechanism from lipid nanocapsules (LNC) | International journal of pharmaceutics |
| 19393270 | 2009-08-04 | Mucoadhesive effect of thiolated PEG stearate and its modified NLC for ocular drug delivery | Journal of controlled release : official journal of the Controlled Release Society |
| 18583110 | 2008-10-01 | Controlled complexation of plasmid DNA with cationic polymers: effect of surfactant on the complexation and stability of the complexes | Colloids and surfaces. B, Biointerfaces |
