Sugammadex Impurity 37
Product Information
Molecular Formula
C6H10O4S2
Molecular Weight
210.27
Description
Sugammadex Impurity 37 is an impurity of sugammadex, a cyclodextrin agent indicated for the treatment of neuromuscular blockade induced by rocuronium and vecuronium. It inactivates rocuronium by encapsulating (chelating) the free molecule to form a stable complex.
Synonyms
3,3'-Dithiobis-propanoic Acid; β,β'-Dithiodipropionic Acid; 2-Carboxyethyl Disulfide; DTDPA; NSC 18841; NSC 677544
IUPAC Name
3-(2-carboxyethyldisulfanyl)propanoic acid
SMILES
C(CSSCCC(=O)O)C(=O)O
InChI
InChI=1S/C6H10O4S2/c7-5(8)1-3-11-12-4-2-6(9)10/h1-4H2,(H,7,8)(H,9,10)
InChI Key
YCLSOMLVSHPPFV-UHFFFAOYSA-N
Boiling Point
155-158 °C
Melting Point
155-158 °C (lit.)
Purity
97 %
Density
1.319 (estimate) g/cm3
Solubility
Soluble in DMSO, Methanol
Appearance
Solid
Storage
-20 °C
Refractive Index
1.5220 (estimate)
LogP
1.31720
Safety Information
Hazards
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
Causes skin irritation.
H319:
Causes serious eye irritation.
Precautionary Statement
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word
Warning
Computed Properties
XLogP3
-0.1
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
7
Exact Mass
210.00205114 g/mol
Monoisotopic Mass
210.00205114 g/mol
Topological Polar Surface Area
125Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
142
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114149543-A | Self-repairing acrylate material and preparation method thereof | 2021-12-16 |
| CN-114041600-A | Preparation method of anthocyanin-loaded phytosterol delivery system | 2021-12-15 |
| CN-113980270-A | Bismaleimide composite material based on disulfide bond and Diels-Alder reaction and preparation method thereof | 2021-12-01 |
| CN-114015050-A | Hyperbranched polysiloxane fluorescent material containing disulfide bond and preparation method thereof | 2021-11-29 |
| CN-114031744-A | Diisocyanate carbomethoxycyclohexane composition, modified composition thereof and preparation method | 2021-11-29 |
| CN-114146177-A | Copper-doped polydopamine nano-drug with stable hydroxyethyl starch prodrug, and preparation and application thereof | 2021-11-24 |
| CN-113845669-A | Double-crosslinked network hydrogel and controllable preparation method thereof | 2021-10-27 |
| CN-113980238-A | Xylylene diisocyanate composition and preparation method and application thereof | 2021-10-27 |
| CN-113912841-A | PH and Redox dual-response diblock amphiphilic polymer prodrug and preparation method thereof | 2021-10-22 |
| CN-114028580-A | Preparation method of podophyllotoxin twin drug nanoparticles | 2021-09-30 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22054172 | 2012-01-31 | Conjugated polymer nanoparticles for light-activated anticancer and antibacterial activity with imaging capability | Langmuir : the ACS journal of surfaces and colloids |
| 21754323 | 2011-05-01 | (OC-6-35)-(2,2'-Bipyridine-κN,N')dimeth-yl(3-sulfido-propionato-κS,O)platinum(IV) | Acta crystallographica. Section E, Structure reports online |
| 20924576 | 2010-11-01 | Investigations on the microbial catabolism of the organic sulfur compounds TDP and DTDP in Ralstonia eutropha H16 employing DNA microarrays | Applied microbiology and biotechnology |
| 19959574 | 2010-04-01 | Biodegradation of the xenobiotic organic disulphide 4,4'-dithiodibutyric acid by Rhodococcus erythropolis strain MI2 and comparison with the microbial utilization of 3,3'-dithiodipropionic acid and 3,3'-thiodipropionic acid | Microbiology (Reading, England) |
| 22163445 | 2010-01-01 | Electrochemical aptasensor for endocrine disrupting 17β-estradiol based on a poly(3,4-ethylenedioxylthiopene)-gold nanocomposite platform | Sensors (Basel, Switzerland) |
| 19543932 | 2009-08-01 | Metabolites from an endophytic fungus sphaceloma sp. LN-15 isolated from the leaves of Melia azedarach | Lipids |
| 19055345 | 2009-01-05 | Anaerobic photocleavage of DNA in red light by dicopper(II) complexes of 3,3'-dithiodipropionic acid | Inorganic chemistry |
| 22291565 | 2009-01-01 | Tiny medicine: nanomaterial-based biosensors | Sensors (Basel, Switzerland) |
| 22346711 | 2009-01-01 | Electroanalytical sensors and devices for multiplexed detection of foodborne pathogen microorganisms | Sensors (Basel, Switzerland) |
| 22408488 | 2009-01-01 | A label-free electronic biosensor for detection of bone turnover markers | Sensors (Basel, Switzerland) |
