TPEN
| Catalog Number | Size | Price | Stock | Quantity |
|---|---|---|---|---|
| BPM-051698 | 1 g | $299 | In stock | |
| BPM-051698 | 10 g | $990 | In stock |
Product Information
Molecular Formula
C26H28N6
Molecular Weight
424.54
Description
TPEN is a heavy metal chelator that acts as an intracellular chelator of proteomic Zn2+. TPEN decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells.
Synonyms
TPEDA; 1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-; N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
IUPAC Name
N,N,N',N'-tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine
SMILES
C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4
InChI
InChI=1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
InChI Key
CVRXLMUYFMERMJ-UHFFFAOYSA-N
Boiling Point
542.1 °C at 760 mmHg (Predicted)
Melting Point
110-112 °C
Flash Point
170.6 °F
Purity
≥98% by HPLC
Density
1.2 g/cm3 (Predicted)
Appearance
Light yellow to Brown powder to crystal
Refractive Index
n20/D 1.442 (lit.)
Safety Information
Hazards
H315 H319
Precautionary Statement
P264 P280 P302 + P352 P337 + P313 P305 + P351 + P338 P362+P364 P332 + P313
Computed Properties
XLogP3
2.1
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Rotatable Bond Count
11
Exact Mass
424.23754492 g/mol
Monoisotopic Mass
424.23754492 g/mol
Topological Polar Surface Area
58Ų
Heavy Atom Count
32
Formal Charge
0
Complexity
419
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114044780-A | Zinc ion near-infrared fluorescent probe and preparation method and application thereof | 2021-11-30 |
| CN-114018908-A | Method for measuring thallium content in gas phase in one step | 2021-11-03 |
| CN-113712965-A | N, N, N application of N' -tetra-group (2-benzyl) -acetamide in preparing medicine for treating UC | 2021-09-18 |
| CN-112934203-A | Heavy metal removing material and method for removing heavy metal in Chinese herbal medicine extract | 2021-02-20 |
| CN-112812203-A | Initiator and preparation method of polymer/metal oxide composite material | 2020-12-22 |
| EP-3967742-A1 | Compositions comprising bleaching catalyst, manufacturing process thereof, and bleaching and cleaning agent comprising same | 2020-09-15 |
| CN-112038671-A | Method and system for estimating temperature distribution of solid oxide fuel cell | 2020-08-21 |
| US-2022050051-A1 | Methods for detecting end-points for cleaning processes of aerospace components | 2020-08-13 |
| WO-2022036112-A1 | Methods for detecting end-points for cleaning processes of aerospace components | 2020-08-13 |
| WO-2022019769-A1 | Bordetella outer membrane vesicles | 2020-07-23 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 33645215 | 2021-03-15 | Impact of the Cellular Zinc Status on PARP-1 Activity and Genomic Stability in HeLa S3 Cells | Chemical research in toxicology |
| 33149232 | 2020-11-04 | Inhibition of red blood cell development by arsenic-induced disruption of GATA-1 | Scientific reports |
| 31162603 | 2019-06-04 | A new function of copper zinc superoxide dismutase: as a regulatory DNA-binding protein in gene expression in response to intracellular hydrogen peroxide | Nucleic acids research |
| 29129814 | 2018-01-15 | Zinc deficiency promotes cystitis-related bladder pain by enhancing function and expression of Cav3.2 in mice | Toxicology |
| 26303504 | 2016-12-01 | Oxidative stress and endocytosis are involved in upregulation of interleukin-8 expression in airway cells exposed to PM2.5 | Environmental toxicology |
| 25209718 | 2014-11-01 | Vacuolar-type H(+)-ATPase subunits and the neurogenic protein big brain are required for optimal copper and zinc uptake | Metallomics : integrated biometal science |
| 24275069 | 2014-01-15 | Arsenite binding-induced zinc loss from PARP-1 is equivalent to zinc deficiency in reducing PARP-1 activity, leading to inhibition of DNA repair | Toxicology and applied pharmacology |
| 22786900 | 2012-08-09 | Induction of autophagy and cell death by tamoxifen in cultured retinal pigment epithelial and photoreceptor cells | Investigative ophthalmology & visual science |
| 22000581 | 2012-08-01 | Zinc deficiency exacerbates diabetic down-regulation of Akt expression and function in the testis: essential roles of PTEN, PTP1B and TRB3 | The Journal of nutritional biochemistry |
| 22539682 | 2012-07-01 | Zinc maintains prophase I arrest in mouse oocytes through regulation of the MOS-MAPK pathway | Biology of reproduction |
