α-Bromoisobutyryl bromide
Product Information
Molecular Formula
C4H6Br2O
Molecular Weight
229.90
Description
α-Bromoisobutyryl bromide has been used: as atom transfer radical polymerization (ATRP) initiator for functionalization of hydroxyl groups present on the surface of graphene oxide; to form an N-protected halodienamide which provided four- and five-membered lactams in the presence of copper (I) and a tertiary amine; in preparation of polycaprolactone macroinitiator via reaction with oligomeric caprolactone diol and mesoporous silica nanoparticles with ATRP initiator anchored on the exterior surface.
Synonyms
2-bromo-2-methylpropanoyl bromide
IUPAC Name
2-bromo-2-methylpropanoyl bromide
SMILES
CC(C)(C(=O)Br)Br
InChI
InChI=1S/C4H6Br2O/c1-4(2,6)3(5)7/h1-2H3
InChI Key
YOCIJWAHRAJQFT-UHFFFAOYSA-N
Boiling Point
162-164 °C (lit.)
Flash Point
235.4 °F
Purity
98 %
Density
1.86 g/cm3
Appearance
Powder
Application
Used to make fine and large scale chemicals.
Storage
2-8 °C
Refractive Index
n20/D 1.507 (lit.)
Stability
Stable, but may react with moisture. Incompatible with water, strong oxidizing agents, strong bases.
LogP
2.08140
Vapor Pressure
2.11mmHg at 25°C
Safety Information
Hazards
H314 H290
Precautionary Statement
P260, P261, P264, P270, P272, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P333+P313, P363, P405, and P501
Signal Word
Danger
Computed Properties
XLogP3
2.2
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
1
Rotatable Bond Count
1
Exact Mass
229.87649 g/mol
Monoisotopic Mass
227.87854 g/mol
Topological Polar Surface Area
17.1Ų
Heavy Atom Count
7
Formal Charge
0
Complexity
87.7
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114134707-A | Preparation process method of antibacterial yarn | 2021-12-29 |
| CN-114149600-A | Preparation method and application of temperature-responsive hydrogel | 2021-12-27 |
| CN-114149588-A | Star initiator and preparation method thereof | 2021-12-23 |
| CN-114059560-A | Inclined pile construction method | 2021-12-22 |
| CN-113956468-A | Synthetic method of polypeptide/polyolefin hybrid copolymer | 2021-12-14 |
| CN-113861264-A | Avidin modification method, application method and kit thereof | 2021-12-03 |
| CN-114085484-A | High-strength high-toughness composite material, preparation method and application | 2021-11-26 |
| CN-114158551-A | Nano pesticide preparation capable of rapidly responding to weak alkaline environment, preparation method and application thereof | 2021-11-22 |
| CN-113930039-A | Bamboo-plastic composite board material for container bottom board | 2021-11-18 |
| CN-114044853-A | Biomass-based EC-g-PSSA graft copolymer and preparation method and application thereof | 2021-11-15 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22575755 | 2012-08-20 | PHEA-graft-polybutylmethacrylate copolymer microparticles for delivery of hydrophobic drugs | International journal of pharmaceutics |
| 22709433 | 2012-07-18 | Star-like oligo-arginyl-maltotriosyl derivatives as novel cell-penetrating enhancers for the intracellular delivery of colloidal therapeutic systems | Bioconjugate chemistry |
| 22524250 | 2012-05-10 | Imidazolopiperazines: lead optimization of the second-generation antimalarial agents | Journal of medicinal chemistry |
| 22701519 | 2012-01-01 | Thermoresponsive micropatterned substrates for single cell studies | PloS one |
| 21882878 | 2011-10-18 | Bifunctional nanoparticles with fluorescence and magnetism via surface-initiated AGET ATRP mediated by an iron catalyst | Langmuir : the ACS journal of surfaces and colloids |
| 22064690 | 2011-10-01 | 2-Bromo-N-(4-chloro-phen-yl)-2-methyl-propanamide | Acta crystallographica. Section E, Structure reports online |
| 21663960 | 2011-09-01 | Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging | Biomaterials |
| 21565356 | 2011-08-15 | Chemical and nanomechanical analysis of rice husk modified by ATRP-grafted oligomer | Journal of colloid and interface science |
| 21563843 | 2011-06-07 | Biomimetic anchors for antifouling and antibacterial polymer brushes on stainless steel | Langmuir : the ACS journal of surfaces and colloids |
| 21277397 | 2011-05-01 | Uniform polymer-protein conjugate by aqueous AGET ATRP using protein as a macroinitiator | Acta biomaterialia |
