N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide
Product Information
Molecular Formula
C7H13NO2
Molecular Weight
143.18
Description
N-(2-hydroxypropyl)methacrylamide (HPMA) is a difunctional, hydrolytically stable, hydrophilic monomer, a building blocks of modified and new biomaterials.
Synonyms
N-(2-hydroxypropyl)-2-methylprop-2-enamide
IUPAC Name
N-(2-hydroxypropyl)-2-methylprop-2-enamide
SMILES
CC(CNC(=O)C(=C)C)O
InChI
InChI=1S/C7H13NO2/c1-5(2)7(10)8-4-6(3)9/h6,9H,1,4H2,2-3H3,(H,8,10)
InChI Key
OKPYIWASQZGASP-UHFFFAOYSA-N
Boiling Point
321.2±34.0 °C (Predicted)
Melting Point
67.92 °C
Purity
98 %
Density
1.002 g/cm3
Appearance
Powder
Storage
Store at 4 degrees celsius
LogP
0.45040
Safety Information
Hazards
Unknown
Precautionary Statement
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word
Warning
Computed Properties
XLogP3
0.3
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
2
Rotatable Bond Count
3
Exact Mass
143.094628657 g/mol
Monoisotopic Mass
143.094628657 g/mol
Topological Polar Surface Area
49.3Ų
Heavy Atom Count
10
Formal Charge
0
Complexity
143
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
1
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114133688-A | Modified water-based organic siloxane-acrylate hybrid resin and preparation and application thereof | 2021-11-29 |
| CN-113786519-A | Preparation method of photocuring hydrophilic coating | 2021-10-11 |
| CN-113786520-A | Preparation method of high-durability hydrophilic coating | 2021-10-11 |
| CN-113908345-A | Preparation method of super-smooth hydrophilic coating | 2021-10-11 |
| CN-113549143-A | Anti-tumor polypeptide Bax-BH3, fluorescent polymer nano micelle and preparation method and application thereof | 2021-07-21 |
| CN-113416315-A | Hyperbranched poly-tertiary amine shale inhibitor | 2021-06-22 |
| CN-113416524-A | High-temperature-resistant hyperbranched poly-tertiary amine as shale inhibitor | 2021-06-22 |
| CN-113350047-A | Anion sanitary towel | 2021-06-03 |
| CN-113150323-A | N- (2-hydroxypropyl) methacrylamide hyaluronic acid hydrogel, preparation method and application | 2021-04-09 |
| CN-113278181-A | Self-cleaning PETG material and application thereof | 2021-01-20 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22795544 | 2012-10-01 | Anti-CD20 multivalent HPMA copolymer-Fab' conjugates for the direct induction of apoptosis | Biomaterials |
| 22930486 | 2012-10-01 | Surfaces resistant to fouling from biological fluids: towards bioactive surfaces for real applications | Macromolecular bioscience |
| 22793269 | 2012-08-13 | Macromolecular HPMA-based nanoparticles with cholesterol for solid-tumor targeting: detailed study of the inner structure of a highly efficient drug delivery system | Biomacromolecules |
| 21893178 | 2012-05-01 | Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery | International journal of pharmaceutics |
| 22204981 | 2012-03-01 | Multifunctional pH-disintegrable micellar nanoparticles of asymmetrically functionalized β-cyclodextrin-based star copolymer covalently conjugated with doxorubicin and DOTA-Gd moieties | Biomaterials |
| 22144261 | 2012-02-06 | RAFT-derived polymer-drug conjugates: poly(hydroxypropyl methacrylamide) (HPMA)-7-ethyl-10-hydroxycamptothecin (SN-38) conjugates | ChemMedChem |
| 22334784 | 2012-01-01 | Synthesis, characterization, and in vivo efficacy evaluation of PGG-docetaxel conjugate for potential cancer chemotherapy | International journal of nanomedicine |
| 22400063 | 2012-01-01 | Protease-activated drug development | Theranostics |
| 22619558 | 2012-01-01 | Effect of intratumoral administration on biodistribution of 64Cu-labeled nanoshells | International journal of nanomedicine |
| 22619725 | 2012-01-01 | Combination drug delivery approaches in metastatic breast cancer | Journal of drug delivery |
