Dextran sulfate sodium salt

Product Information

Description
Dextran sulfate sodium salt is a long chain polymer of sulfated glucose, containing 17 - 20% sulfur. It has been used as an anticoagulant and has been shown to inhibit the binding of HIV-1 to CD4+ T lymphocytes. It is used to accelerate hybridization of DNA probes to immobilized nucleic acids.
Synonyms
Dextran sulfate sodium salt from Leuconostoc sp.; Asuro; Colyonal; Dexnon; Dextralip 15; Dextran sodium sulfate; Dextran sulfate sodium; Dextran, hydrogen sulfate, sodium salt; Dextran sulfuric acid ester sodium salt; Dextransulfate sodium sulfur; Dextrarine; Dexulate; MDS; MDS (polysaccharide); MDS-Kowa A; Sodium dextran sulfate
Solubility
Soluble in DMSO, Water
Appearance
White to off-white powder
Application
Used as a local anesthetic.
Storage
Cool and dry place.
Viscosity
0.1-0.7 in 1M AQ NaCl
Stability
Stable in air.
LogP
log Kow = 1.86
Vapor Pressure
2.6X10-4 mm Hg at 25 °C /Estimated
Henry's Law Constant
1.6X10-8 atm-cu m/mole at 25 °C /Estimated/
Dissociation Constants
2.51 (at 25 °C)

Safety Information

Hazards
Harmless-use normal precautions
Handling
Exercise normal care

Molecular Weight

MW 4500-5500
MW 5,000-8,000
MW 6,000-10,000
MW 8,000
MW 9,000-11,000
MW 20,000
MW 40,000
MW 50,000
MW 80,000
MW 100,000
MW 150,000
MW 500,000

Computed Properties

XLogP3
1.9
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
3
Exact Mass
165.078978594 g/mol
Monoisotopic Mass
165.078978594 g/mol
Topological Polar Surface Area
52.3Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
151
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes

Patents

Publication Number Title Priority Date
JP-2022042517-A External composition for the scalp 2021-12-24
JP-2022031355-A Pest control method 2021-12-15
CN-114032337-A Respiratory tract pathogen detection kit and preparation method and application thereof 2021-12-14
CN-114099478-A Oral wound protective film and preparation method thereof 2021-12-02
JP-2022031761-A How to improve the solubility of poorly water-soluble ingredients 2021-11-22
JP-2022036981-A Cosmetic blend 2021-11-19
CN-114042448-A Preparation method and application of Mn-MOF-based two-dimensional sheet manganese oxide/mesoporous carbon catalyst 2021-11-18
CN-114113378-A Method for detecting content of lafutidine tablet 2021-11-11
JP-2022010128-A Evaluation base material manufacturing method and evaluation base material manufacturing equipment 2021-11-08
CN-113956242-A Photosensitizer for inducing immunogenic cell death and preparation method and application thereof 2021-10-29

Literatures

PMID Publication Date Title Journal
36543318 2023-01-25 Protective effect of 7-hydroxyl-1-methylindole-3-acetonitrile on the intestinal mucosal damage response to inflammation in mice with DSS-induced colitis Chemico-biological interactions
36126765 2022-11-01 Hainanolide inhibits the progression of colon cancer via inducing the cell cycle arrest, cell apoptosis and activation of the MAPK signaling pathway Toxicology and applied pharmacology
36265525 2022-11-01 RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice Toxicology
35670535 2022-09-01 MicroRNA-9a-5p inhibits mucosal barrier injury in inflammatory bowel disease Journal of biochemical and molecular toxicology
35999755 2022-09-01 Uncovering the functions of plasma proteins in ulcerative colitis and identifying biomarkers for BPA-induced severe ulcerative colitis: A plasma proteome analysis Ecotoxicology and environmental safety
35439472 2022-07-01 Obeticholic acid orchestrates the crosstalk between ileal autophagy and tight junctions in non-alcoholic steatohepatitis: Role of TLR4/TGF-β1 axis Chemico-biological interactions
34964214 2022-04-01 Association of Type 1 diabetes with ulcerative colitis in BALB/c mice: Investigations on sex-specific differences Journal of biochemical and molecular toxicology
35217026 2022-03-15 The protective effect of safranal against intestinal tissue damage in Drosophila Toxicology and applied pharmacology
35093514 2022-03-01 Metabolomic and transcriptomic responses of mouse testis to the dextran sulfate sodium induced colitis Reproductive toxicology (Elmsford, N.Y.)
34998820 2022-02-01 Oral benzo[a]pyrene administration attenuates dextran sulfate sodium-induced colitis in mice Chemico-biological interactions
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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