Dextran sulfate sodium salt
Product Information
Description
Dextran sulfate sodium salt is a long chain polymer of sulfated glucose, containing 17 - 20% sulfur. It has been used as an anticoagulant and has been shown to inhibit the binding of HIV-1 to CD4+ T lymphocytes. It is used to accelerate hybridization of DNA probes to immobilized nucleic acids.
Synonyms
Dextran sulfate sodium salt from Leuconostoc sp.; Asuro; Colyonal; Dexnon; Dextralip 15; Dextran sodium sulfate; Dextran sulfate sodium; Dextran, hydrogen sulfate, sodium salt; Dextran sulfuric acid ester sodium salt; Dextransulfate sodium sulfur; Dextrarine; Dexulate; MDS; MDS (polysaccharide); MDS-Kowa A; Sodium dextran sulfate
Solubility
Soluble in DMSO, Water
Appearance
White to off-white powder
Application
Used as a local anesthetic.
Storage
Cool and dry place.
Viscosity
0.1-0.7 in 1M AQ NaCl
Stability
Stable in air.
LogP
log Kow = 1.86
Vapor Pressure
2.6X10-4 mm Hg at 25 °C /Estimated
Henry's Law Constant
1.6X10-8 atm-cu m/mole at 25 °C /Estimated/
Dissociation Constants
2.51 (at 25 °C)
Related CAS
9004-54-0 (free base) 50935-35-8 (Deleted CAS) 57972-02-8 (Deleted CAS) 207464-10-6 (Deleted CAS)
Safety Information
Hazards
Harmless-use normal precautions
Handling
Exercise normal care
Molecular Weight
MW 4500-5500
MW 5,000-8,000
MW 6,000-10,000
MW 8,000
MW 9,000-11,000
MW 20,000
MW 40,000
MW 50,000
MW 80,000
MW 100,000
MW 150,000
MW 500,000
Computed Properties
XLogP3
1.9
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Rotatable Bond Count
3
Exact Mass
165.078978594 g/mol
Monoisotopic Mass
165.078978594 g/mol
Topological Polar Surface Area
52.3Ų
Heavy Atom Count
12
Formal Charge
0
Complexity
151
Isotope Atom Count
0
Defined Atom Stereocenter Count
0
Undefined Atom Stereocenter Count
0
Defined Bond Stereocenter Count
0
Undefined Bond Stereocenter Count
0
Covalently-Bonded Unit Count
1
Compound Is Canonicalized
Yes
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| JP-2022042517-A | External composition for the scalp | 2021-12-24 |
| JP-2022031355-A | Pest control method | 2021-12-15 |
| CN-114032337-A | Respiratory tract pathogen detection kit and preparation method and application thereof | 2021-12-14 |
| CN-114099478-A | Oral wound protective film and preparation method thereof | 2021-12-02 |
| JP-2022031761-A | How to improve the solubility of poorly water-soluble ingredients | 2021-11-22 |
| JP-2022036981-A | Cosmetic blend | 2021-11-19 |
| CN-114042448-A | Preparation method and application of Mn-MOF-based two-dimensional sheet manganese oxide/mesoporous carbon catalyst | 2021-11-18 |
| CN-114113378-A | Method for detecting content of lafutidine tablet | 2021-11-11 |
| JP-2022010128-A | Evaluation base material manufacturing method and evaluation base material manufacturing equipment | 2021-11-08 |
| CN-113956242-A | Photosensitizer for inducing immunogenic cell death and preparation method and application thereof | 2021-10-29 |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 36543318 | 2023-01-25 | Protective effect of 7-hydroxyl-1-methylindole-3-acetonitrile on the intestinal mucosal damage response to inflammation in mice with DSS-induced colitis | Chemico-biological interactions |
| 36126765 | 2022-11-01 | Hainanolide inhibits the progression of colon cancer via inducing the cell cycle arrest, cell apoptosis and activation of the MAPK signaling pathway | Toxicology and applied pharmacology |
| 36265525 | 2022-11-01 | RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice | Toxicology |
| 35670535 | 2022-09-01 | MicroRNA-9a-5p inhibits mucosal barrier injury in inflammatory bowel disease | Journal of biochemical and molecular toxicology |
| 35999755 | 2022-09-01 | Uncovering the functions of plasma proteins in ulcerative colitis and identifying biomarkers for BPA-induced severe ulcerative colitis: A plasma proteome analysis | Ecotoxicology and environmental safety |
| 35439472 | 2022-07-01 | Obeticholic acid orchestrates the crosstalk between ileal autophagy and tight junctions in non-alcoholic steatohepatitis: Role of TLR4/TGF-β1 axis | Chemico-biological interactions |
| 34964214 | 2022-04-01 | Association of Type 1 diabetes with ulcerative colitis in BALB/c mice: Investigations on sex-specific differences | Journal of biochemical and molecular toxicology |
| 35217026 | 2022-03-15 | The protective effect of safranal against intestinal tissue damage in Drosophila | Toxicology and applied pharmacology |
| 35093514 | 2022-03-01 | Metabolomic and transcriptomic responses of mouse testis to the dextran sulfate sodium induced colitis | Reproductive toxicology (Elmsford, N.Y.) |
| 34998820 | 2022-02-01 | Oral benzo[a]pyrene administration attenuates dextran sulfate sodium-induced colitis in mice | Chemico-biological interactions |
